2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. CDK1-IN-8

CDK1-IN-8 是一种 CDK1 抑制剂。CDK1-IN-8 可抑制细胞迁移、诱导细胞凋亡 (apoptosis)，并将细胞周期阻滞在 G2/M 期。CDK1-IN-8 可显著下调 HepG2 细胞中 CDK1 蛋白的表达水平。CDK1-IN-8 可用于研究肝细胞癌。

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CDK1-IN-8

CDK1-IN-8 Chemical Structure

CAS No. : 3077717-99-5

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CDK1-IN-8 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK1-IN-8 is a CDK1 inhibitor. CDK1-IN-8 inhibits cell migration, induces apoptosis, and arrests the cell cycle at the G2/M phase. CDK1-IN-8 leads to a significant downregulation of CDK1 protein levels in HepG2 cells. CDK1-IN-8 can be used for the study of hepatocellular carcinoma[1].

IC50 & Target[1]

CDK1

 

体外研究
(In Vitro)

CDK1-IN-8 (Compound c9) 对 HepG2 细胞表现出最强的抑制活性 (IC50 为 11.88 μM)。在正常 L02 肝细胞中，IC50 为 95.48 μM，选择性指数 SI = 8.0[1]。
CDK1-IN-8 (10-20 μM，48 h) 显著抑制 HepG2 细胞的体外迁移能力，提示其具有潜在的抗肿瘤转移作用[1]。
CDK1-IN-8 (0-5 μM，48 h) 诱导 HepG2 细胞发生显著的剂量依赖性凋亡[1]。
CDK1-IN-8 (0-15 μM，48 h) 通过诱导细胞周期阻滞于 G2/M 期抑制 HepG2 细胞增殖[1]。
CDK1-IN-8 (2.5-15 μM，48 h) 显著且剂量依赖性地降低 HepG2 细胞中 CDK1 蛋白的表达水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK1-IN-8 相关抗体:

Cell Migration Assay [1]

Cell Line: HepG2 cells
Concentration: 10 μM, 15 μM, 20 μM
Incubation Time: 48 h
Result: Significantly and in a dose-dependent manner inhibited the migration of HepG2 cells to the scratch area; at 20 μM, the scratch closure rate was only 3.70%.

ELISA Assay[1]

Cell Line: HepG2 cells
Concentration: 0 μM, 2.5 μM, 5 μM, 7.5 μM, 10 μM, 15 μM
Incubation Time: 48 h
Result: At a concentration of 15 μM, reduced CDK1 expression.
分子量

604.95

Formula

C28H27ClFN2O8P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK1-IN-8 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK1-IN-83077717-99-5CDKApoptosisCyclin dependent kinaseRheinPhosphorylationCDK1 inhibitorHepatocellular carcinomaMolecular dynamics simulationCell-cycle arrestInhibitorinhibitorinhibit

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