2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. CDK Reactive Oxygen Species (ROS) SOD
  4. CDK4/6-IN-26

CDK4/6-IN-26 是一种靶向 CDK4/CDK6 的氨基甲酸酯衍生物。CDK4/6-IN-26 降低 CDK4/CDK6 的水平，导致细胞周期停滞于 G0/G1 期和 S 期。CDK4/6-IN-26 对 SW480 细胞具有很高的活性 (IC50 = 6.3 μM)。CDK4/6-IN-26 通过增加 SOD2/MnSOD 的表达来影响 ROS 水平。CDK4/6-IN-26 与 CDK6 活性位点的氨基酸形成多种相互作用。CDK4/6-IN-26 可用于结直肠癌的研究。

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CDK4/6-IN-26

CDK4/6-IN-26 Chemical Structure

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Customer Review

CDK4/6-IN-26 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK4/6-IN-26 is a carbamate derivative that targets CDK4/CDK6. CDK4/6-IN-26 reduces CDK4/CDK6 levels, resulting in cell cycle arrest in the G0/G1 phase and in the S phase. CDK4/6-IN-26 exhibits high potency against SW480 cells (IC50 = 6.3 μM). CDK4/6-IN-26 affects ROS levels by increasing the expression of SOD2/MnSOD. CDK4/6-IN-26 establishes several interactions with the amino acids of the CDK6 active site. CDK4/6-IN-26 can be used for the research of colorectal cancer[1].

IC50 & Target[1]

CDK4

 

CDK6

 

体外研究
(In Vitro)

CDK4/6-IN-26 (compound 17) (6.3 μM; 72 h; SW480) 通过延长细胞倍增时间，从而降低细胞生长速率，影响了 SW480 细胞的生长模式[1]。
CDK4/6-IN-26 (6.3 μM; 24-72 h; SW480) 在 24 小时内显示细胞周期在 G0/G1 期停滞，在 48 小时内则在 S 期停滞。72 小时后，CDK4/6-IN-26 对 SW480 细胞的细胞周期没有影响[1]。
CDK4/6-IN-26 (6.3 μM；24-72 小时；SW480) 降低 CDK4/6、cyclin A 和 Rb 蛋白的水平，并增加 SOD2/MnSOD 的表达[1]。
CDK4/6-IN-26 (72 h) 可抑制 SW480、SW620、HCT116、Caco-2、Mia Paca-2 和 A375 细胞的活力，其 IC50 值分别为 6.3 μM、10 μM、17 μM、16 μM、7.5 μM 和 6.7 μM。CDK4/6-IN-26 对正常细胞的增殖没有影响[1]。
CDK4/6-IN-26 (6.3 μM；24-72 小时；SW480) 不会诱导 SW480 细胞凋亡[1]。
CDK4/6-IN-26 (6.3 μM；24-72 小时；SW480) 在 24 小时内降低 ROS 水平，并在 48-72 小时内增加 ROS 水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK4/6-IN-26 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SW480 cells
Concentration: 6.3 μM
Incubation Time: 24, 48 or 72 h
Result: Affected the growth pattern of SW480 cells by increasing the cell doubling time, consequently decreasing the cell growth rate.

Cell Cycle Analysis[1]

Cell Line: SW480
Concentration: 6.3 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Induced cell cycle arrest at the G0/G1 phase at 24 h and in the S phase at 48 h

Western Blot Analysis[1]

Cell Line: SW480
Concentration: 6.3 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Decreased levels of CDK4/6 proteins and cyclin A at 24 h and 48 h, and decreased Rb protein levels at all time points Increased expression of SOD2/MnSOD at 24 h and 72 h.
分子量

487.63

Formula

C28H41NO6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK4/6-IN-26 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK4/6-IN-26CDKReactive Oxygen Species (ROS)SODCyclin dependent kinaseSuperoxide DismutaseCDK6,CDK4,colorectal cancer,SOD2/MnSOD,ROSInhibitorinhibitorinhibit

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