2. Cell Cycle/DNA Damage Stem Cell/Wnt Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. CDK Wnt β-catenin c-Myc Reactive Oxygen Species (ROS)
  4. CDK8-IN-20

CDK8-IN-20 (Compound 67j) 是一种选择性强、效力高且具有口服活性的 I 型 CDK8 抑制剂，其 IC50 值为 70.5 nM。CDK8-IN-20 对同源激酶 CDK19、CDK7 和 CDK9 的 IC50 值分别为 147.8、726.9 和 217.4 nM。CDK8-IN-20 能够抑制 Wnt/β-catenin 通路，并下调 β-catenin、Cyclin D1 和 c-Myc 的表达。CDK8-IN-20 可以诱导活性氧 (ROS) 的产生，并导致 G2/M 期和 S 期阻滞。CDK8-IN-20 可用于癌症研究，如结肠癌。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CDK8-IN-20

CDK8-IN-20 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

CDK8-IN-20 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

查看 Wnt 亚型特异性产品:

查看所有亚型
Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CDK8-IN-20 (Compound 67j) is a selective, potent and orally active type I CDK8 inhibitor with an IC50 of 70.5 nM. CDK8-IN-20 shows IC50 values of 147.8, 726.9 and 217.4 nM for homologous kinase CDK19, CDK7 and CDK9. CDK8-IN-20 can inhibit the Wnt/β-catenin pathway and downregulate the expression of β-catenin, Cyclin D1, and c-Myc. CDK8-IN-20 can induce ROS production and cause G2/M and S phase arrest. CDK8-IN-20can be used for the research of cancer, such as colon cancer[1].

IC50 & Target[1]

CDK8

70.5 nM (IC50)

CDK19

147.8 nM (IC50)

CDK9

217.4 nM (IC50)

CDK7

726.9 nM (IC50)

体外研究
(In Vitro)

CDK8-IN-20 能够抑制 HCT-116、HT-29 和 SW-480 细胞的增殖，其 IC50 值分别为 5.9、17.93 和 9.52 μM，并且对正常胃黏膜上皮细胞 GES-1 的细胞毒性较低 (IC50 大于 100 μM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CDK8-IN-20 相关抗体:
分子量

469.51

Formula

C22H23N5O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CDK8-IN-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK8-IN-20CDKWntβ-cateninc-MycReactive Oxygen Species (ROS)Cyclin dependent kinaseBeta cateninMycInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CDK8-IN-20
目录号：
HY-180124
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z