1. Membrane Transporter/Ion Channel
  2. ASCT
  3. cis-3-Hydroxyproline

cis-L-3-Hydroxyproline 是 丙氨酸-丝氨酸-半胱氨酸转运体 2 (ASCT2, SLC1A5) 的底物,能诱导内向阴离子电流,并与 ASCT2 结合位点残基 (包括 Asn471) 形成关键相互作用。cis-L-3-Hydroxyproline 可用于黑色素瘤的研究。

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cis-3-Hydroxyproline

cis-3-Hydroxyproline Chemical Structure

CAS No. : 567-35-1

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  • 生物活性

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生物活性

cis-L-3-Hydroxyproline is an Alanine-Serine-Cysteine transporter 2 (ASCT2, SLC1A5) substrate that can induces inwardly-directed anion current, and forms key interactions with ASCT2 binding site residues including Asn471.cis-L-3-Hydroxyproline can be used for the research of melanoma[1].

体外研究
(In Vitro)

cis-L-3-Hydroxyproline (0-5 mM) 可在表达 ASCT2 的 HEK293 细胞中激活 ASCT2,其 Km 值为 0.019 ± 0.01 mM,诱导产生的最大电流是 1 mM 丙氨酸的 1.39 倍[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

131.13

Formula

C5H9NO3

CAS 号
性状

固体

结构分类
初始来源

Streptomyces sp

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献
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产品名称:
cis-3-Hydroxyproline
目录号:
HY-78162
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