2. Apoptosis Immunology/Inflammation
  3. Pyroptosis
  4. CQ80

CQ80 是 PEPD/XPNPEP1 抑制剂及选择性 CARD8 炎性小体激活剂，对 PEPD、XPNPEP1 的 IC50 分别为 0.91 μM、43 μM。CQ80 通过抑制 PEPD 和 XPNPEP1 促进 Xaa-Pro 肽的积累，释放 CARD8 片段以形成炎症小体，并通过切割 GSDMD 诱导细胞焦亡 (pyroptosis)。CQ80 可用于炎性小体、CARD8 表达癌细胞、 HIV-1 感染细胞清除、急性髓系白血病 (AML) 相关研究。

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CQ80

CQ80 Chemical Structure

CAS No. : 3034207-17-2

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CQ80 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CQ80 is a PEPD/XPNPEP1 inhibitor and selective CARD8 inflammasome activator. CQ80 has IC50 values of 0.91 μM for PEPD, 43 μM for XPNPEP1. CQ80 promotes the accumulation of Xaa-Pro peptides by inhibiting PEPD and XPNPEP1, releases the fragment of CARD8 for inflammasome formation, and induces pyroptosis via GSDMD cleavage. CQ80 can be used for research on inflammasome, CARD8-expressing cancer cells, HIV-1-infected cell clearance, acute myeloid leukemia (AML)[1].

体外研究
(In Vitro)

CQ80 (0.15 nM-100 μM；24 h) 诱导 MV4-11 细胞发生 CASP1 依赖的焦亡，IC50 为 0.27 μM，并对 OCI-AML2 细胞表现出强效细胞毒性[1]。
CQ80 (6.25 μM；6 h) 促进 MV4-11 和 OCI-AML2 细胞摄取 Propidium Iodide (PI) (HY-D0815)，表明细胞发生溶解性细胞死亡[1]。
CQ80 (20 μM；24 h) 诱导 MV4-11、OCI-AML2、THP-1 细胞及人静息 T 细胞释放乳酸脱氢酶 (LDH) 并发生 GSDMD 切割[1]。
CQ80 (20 μM；24 h) 在 N/TERT-1 角质形成细胞、小鼠骨髓来源巨噬细胞 (BMDMs) 和 RAW264.7 细胞中无活性，无法激活 NLRP1 炎性小体[1]。
CQ80 (20 μM；24 h) 在 DPP8/9 敲除 THP-1 细胞中不诱导额外焦亡，且 PEPD/XPNPEP1 双敲除 THP-1 细胞对 CQ80 完全耐受[1]。
CQ80 (20 μM；6 h) 在稳定表达 CASP1 和 GSDMD 的 HEK293T 细胞中破坏 CARD8-DPP9 三元复合物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CQ80 相关抗体:

Cell Viability Assay[1]

Cell Line: MV4-11 WT cells, MV4-11 CASP1⁻/⁻ cells, OCI-AML2 cells
Concentration: 100 μM to 15.2 nM (three-fold dilutions)
Incubation Time: 24 h
Result: Induced CASP1-dependent cell death in MV4-11 WT cells, with no such effect in MV4-11 CASP1⁻/⁻ cells; Exhibited higher cytotoxicity against OCI-AML2 cells compared to CQ31.

Western Blot Analysis[1]

Cell Line: THP-1 cells, THP-1 PEPD/XPNPEP1⁻/⁻ cells, MV4-11 cells, OCI-AML2 cells, human resting T cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Detected GSDMD cleavage bands, while no such bands were found in THP-1 PEPD/XPNPEP1⁻/⁻ cells

Western Blot Analysis[1]

Cell Line: HEK293T CASP1+GSDMD cells
Concentration: 20 μM
Incubation Time: 6 h
Result: GSDMD cleavage bands were detected in HEK293T cells after combined treatment with dTAG-13
分子量

385.50

Formula

C19H35N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CQ80 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CQ803034207-17-2CQ 80CQ-80PyroptosisPEPD/XPNPEP1 inhibitorselective CARD8 inflammasome activatorinduces pyroptosisMV4-11 cellsOCI-AML2 cellsTHP-1 cellsHEK 293T cellsRAW264.7 cellshuman resting T cellsmouse bone marrow-derived macrophages (BMDMs)acute myeloid leukemia (AML)HIV-1 infectioninflammasomeInhibitorinhibitorinhibit

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产品名称：
CQ80
目录号：
HY-185207
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