2. PROTAC Apoptosis NF-κB
  3. PROTACs Caspase NF-κB Apoptosis
  4. dCASP1-55

dCASP1-55 是一种 cereblon 依赖型的半胱天冬酶-1 (CASP1) PROTAC 降解剂。dCASP1-55 可在白血病细胞中诱导过度的 NF-κB 激活、细胞凋亡 (apoptosis) 以及中度 S 期阻滞。dCASP1-55 能够抑制白血病细胞的集落形成。dCASP1-55 可用于癌症相关研究，例如髓系恶性肿瘤和急性髓系白血病。

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dCASP1-55

dCASP1-55 Chemical Structure

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Customer Review

dCASP1-55 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

dCASP1-55 is a cereblon-dependent caspase-1 (CASP1) PROTAC degrader. dCASP1-55 induces excessive NF-κB activation, apoptosis, and moderate S-phase arrest in leukemic cells. dCASP1-55 suppresses colony formation of leukemic cells. dCASP1-55 can be used for the research of cancer, such as myeloid malignancies and acute myeloid leukemia[1].

IC50 & Target[1]

Caspase-1

 

Cereblon

 

体外研究
(In Vitro)

dCASP1-55 (25-1000 nM；0-6 h) 可在 THP1、MDSL 及 AML 细胞中选择性降解 CASP1，抑制这些细胞的集落形成，诱导过度的 NF-κB 激活，同时诱导细胞凋亡和中度 S 期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

dCASP1-55 相关抗体:

Western Blot Analysis[1]

Cell Line: THP1, MDSL, and AML cells
Concentration: 50, 100, 200 and 300 nM
Incubation Time: 6 h
Result: Decreased CASP1 levels.
Increased p-RelA levels.
分子量

968.40

Formula

C45H54ClN7O15
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

dCASP1-55 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dCASP1-55PROTACsCaspaseNF-κBApoptosisNuclear factor-κBNuclear factor-kappaBapoptosismyeloid malignanciesleukemicPro-CASP1cereblonacute myeloid leukemiaInhibitorinhibitorinhibit

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产品名称：
dCASP1-55
目录号：
HY-181132
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