2. JAK/STAT Signaling Apoptosis PI3K/Akt/mTOR MAPK/ERK Pathway Protein Tyrosine Kinase/RTK Stem Cell/Wnt
  3. EGFR Akt Hedgehog GSK-3 Apoptosis ERK
  4. Degalactotigonin

Degalactotigonin 是靶向 EGFR、GSK3β 及 Hedgehog/Gli1 通路的皂苷类选择性抑制剂，能够从龙葵 (Solanum nigrum) 中分离得到。Degalactotigonin 抑制 EGFR 磷酸化及下游 Akt/ERK 信号通路，同时通过 GSK3β 失活抑制 Hedgehog/Gli1 通路，进而诱导癌细胞凋亡 (apoptosis)、阻滞细胞周期并抑制迁移侵袭。Degalactotigonin 可应用于胰腺癌、骨肉瘤等恶性肿瘤的靶向研究。

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Degalactotigonin

Degalactotigonin Chemical Structure

CAS No. : 39941-51-0

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Degalactotigonin 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 GSK-3 亚型特异性产品:

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GSK-3 GSK-3α GSK-3β

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and Hedgehog/Gli1 pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma[1][2].

IC50 & Target

GSK-3β

 

分子量

1035.17

Formula

C50H82O22
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Degalactotigonin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Degalactotigonin39941-51-0EGFRAktHedgehogGSK-3ApoptosisERKEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BGlycogen synthase kinase-3Glycogen synthase kinase 3Extracellular signal regulated kinasesInhibitorinhibitorinhibit

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