2. Metabolic Enzyme/Protease Apoptosis Cytoskeleton
  3. LDLR Heme Oxygenase (HO) TNF Receptor Integrin
  4. Desferricoprogen

Desferricoprogen 是一种疏水性真菌铁螯合载体。Desferricoprogen 可减少动脉粥样硬化饮食饲喂的 ApoE−/− 小鼠的动脉粥样硬化斑块形成，并抑制其主动脉根部的脂质过氧化。Desferricoprogen 能够降低氧化型低密度脂蛋白 (oxLDL) 水平，并抑制 oxLDL 诱导的 HO-1、CD36 和 TNF-α mRNA 表达。Desferricoprogen 可抑制 TNF-α 诱导的内皮细胞活化、VCAM-1、ICAM-1 表达，并维持内皮单层完整性。Desferricoprogen 可用于动脉粥样硬化的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Desferricoprogen

Desferricoprogen Chemical Structure

CAS No. : 30315-65-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Desferricoprogen 相关抗体

Top Publications Citing Use of Products

查看 Heme Oxygenase (HO) 亚型特异性产品:

查看所有亚型
HO-1 HO-2

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Integrin 亚型特异性产品:

查看所有亚型
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Desferricoprogen is a hydrophobic fungal iron chelator siderophore. Desferricoprogen reduces atherosclerotic plaque formation and inhibits lipid peroxidation in aortic roots in ApoE−/− mice on an atherogenic diet. Desferricoprogen can lower the level of oxidized LDL (oxLDL) and inhibit oxLDL-induced HO-1, CD36, and TNF-α mRNA expression. Desferricoprogen inhibits TNF-α-induced endothelial cell activation, VCAM-1, ICAM-1 experssion and preserves endothelial monolayer integrity. Desferricoprogen can be used for the research of atherosclerosis[1][2].

IC50 & Target[1]

HO-1

 

体外研究
(In Vitro)

Desferricoprogen (50 μM；2 h) 可抑制由血红素或 H2O2 催化的低密度脂蛋白 (LDL) 氧化[1]。
Desferricoprogen (50 μM；16 h) 可抑制由血红素或血红蛋白催化的人斑块脂质氧化[1]。
Desferricoprogen (50 μM；预孵育 16 h) 可抑制 TNF-α 诱导的人脐静脉内皮细胞 (HUVEC) 中 VCAM-1 和 ICAM-1 的表达，并维持内皮细胞单层完整性[1]。
Desferricoprogen (50 μM；预孵育 16 h) 可抑制 TNF-α 诱导的单核细胞与 HUVEC 的黏附作用[1]。
Desferricoprogen (50 μM；预孵育 16 h) 可保护人脐静脉内皮细胞 (HUVEC) 和 RAW 264.7 巨噬细胞免受氧化型低密度脂蛋白 (oxLDL) 诱导的细胞毒性损伤[1]。
Desferricoprogen (50 μM；预孵育 16 小时) 可抑制暴露于 LDL-血红素溶液的 RAW 264.7 巨噬细胞中泡沫细胞的形成[1]。
Desferricoprogen (50 μM；预孵育 16 小时) 可抑制 oxLDL 诱导的 RAW 264.7 巨噬细胞中 HO-1、CD36 和 TNF-α 的 mRNA 表达 [1]。
Desferricoprogen (20 μM；4 小时) 可抑制细胞毒性 LDL 产物的生成，保护 HUVECs 免受血红素氧化 LDL 介导的细胞毒性作用[2]。
Desferricoprogen (20 μM；预孵育 2 小时后进行细胞处理) 可抑制血红素氧化型低密度脂蛋白诱导的人脐静脉内皮细胞 (HUVECs) 中 HO-1 mRNA 上调及酶活性 [2]。
Desferricoprogen (25-50 μM；24-48 h) 可暂时抑制人动脉粥样硬化斑块中血红素介导的脂质过氧化，在 50 μM 浓度下抑制作用可持续长达 24 小时[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Desferricoprogen 相关抗体:

Real Time qPCR[1]

Cell Line: RAW 264.7 macrophages
Concentration: 50 μM
Incubation Time: 16 h (pre-incubation); 6 h (oxLDL treatment)
Result: Inhibited oxLDL-induced HO-1 mRNA expression, CD36 mRNA expression, and TNF-α mRNA expression.

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial cells (HUVECs)；RAW 264.7 macrophages
Concentration: 50 μM
Incubation Time: 16 h (pre-incubation); 8 h (TNF-α treatment)
Result: Decresded VCAM-1 and ICAM-1 expression in HUVECs.
Decresded HO-1 expression in HUVECs and RAW 264.7 macrophages.
体内研究
(In Vivo)

Desferricoprogen (160 mg/kg；腹腔注射；每两日一次；持续 8 周) 可抑制饲喂致动脉粥样硬化饲料的 ApoE−/− 小鼠的动脉粥样硬化斑块形成、脂质过氧化及 VCAM-1 表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Apolipoprotein E-deficient (ApoE⁻/⁻) mice with atherogenic diet (C57BL6; 8 weeks old)[1]
Dosage: 160 mg/kg
Administration: I.p.; every second day; 8 weeks
Result: Reduced atherosclerotic plaque burden in the total aorta.
Lowered plasma oxidized LDL (oxLDL) levels and decreased lipid peroxidation in aortas.
Inhibited vascular cell adhesion molecule-1 (VCAM-1) expression in aortas.
Decreased lipid accumulation and elastin deposition in aortic roots.
分子量

768.86

Formula

C35H56N6O13
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Desferricoprogen 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desferricoprogen30315-65-2LDLRHeme Oxygenase (HO)TNF ReceptorIntegrinLow-density lipoprotein receptorHeme OxygenaseTumor Necrosis Factor ReceptorTNFRRAW 264.7macrophagesendothelial cellsaortic atheromasVCAM-1heme oxygenase-1oxLDLTNF-αCD36ApoE?/?Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Desferricoprogen
目录号：
HY-180385
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z