2. PROTAC Immunology/Inflammation Apoptosis
  3. Molecular Glues IKZF Family Apoptosis
  4. DIX-01

DIX-01 是一种分子胶降解剂，能够同时诱导 CRBN 介导的 IKZF1/3 和 GSPT1 降解，其 DC50 值分别为：IKZF1 (19.80 nM)、IKZF3 (45.31 nM) 和 GSPT1 (120.1 nM)。DIX-01 在多种癌细胞系中表现出纳摩尔级别的强效抗增殖活性。DIX-01 诱导 MV4-11 细胞凋亡 (apoptosis)，显著抑制斑马鱼体内白血病细胞的生长。DIX-01 可用于研究恶性血液肿瘤。

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DIX-01

DIX-01 Chemical Structure

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DIX-01 相关抗体

Top Publications Citing Use of Products

查看 IKZF Family 亚型特异性产品:

查看所有亚型
IKZF1 IKZF2 IKZF3 IKZF4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DIX-01 is a molecular gel degrader that can simultaneously induce the degradation of IKZF1/3 and GSPT1 mediated by CRBN. Its DC50 values are: IKZF1 (19.80 nM), IKZF3 (45.31 nM), and GSPT1 (120.1 nM). DIX-01 exhibits nanomolar-level potent anti-proliferative activity in various cancer cell lines. DIX-01 induces apoptosis in MV4-11 cells and significantly inhibits the growth of leukemia cells in zebrafish. DIX-01 can be used for the study of malignant hematological tumors[1].

IC50 & Target[1]

IKZF1

19.80 nM (DC50)

IKZF3

45.31 nM (DC50)

分子量

538.59

Formula

C31H30N4O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DIX-01 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DIX-01DIX01DIX 01Molecular GluesIKZF FamilyApoptosisIkaros zinc finger protein familyMolecular glueIKZF1/3GSPT1Dual-targetAcute myelogenous leukemiaMolecular dynamics simulationInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-180836
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