2. Anti-infection
  3. Fungal
  4. Fosmanogepix TFA

Fosmanogepix TFA (APX001 TFA) 是一种具有口服活性的 APX001A (HY-18233) 前药及抗真菌 (Antifungal) 剂。Fosmanogepix TFA 对新型隐球菌、Fluconazole (HY-B0101) 耐受的耳念珠菌均有效。Fosmanogepix TFA 可有效改善侵袭性肺曲霉病和小鼠肺毛霉病。

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Fosmanogepix TFA

Fosmanogepix TFA Chemical Structure

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Fosmanogepix TFA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fosmanogepix TFA (APX001 TFA) is an orally active APX001A (HY-18233) prodrug and antifungal agent. Fosmanogepix TFA is effective against Cryptococcus neoformans, Fluconazole (HY-B0101)-resistant C. auris. Fosmanogepix TFA is effective in the treatment of invasive pulmonary aspergillosis and pulmonary murine mucormycosis[1][2][3][4].

体内研究
(In Vivo)

Fosmanogepix (390 mg/kg；口服；每日三次；7 天) TFA 在隐球菌脑膜炎小鼠模型中，可降低真菌载量[1]。
Fosmanogepix (78-264 mg/kg；口服；每日一次或两次；3-7 天) TFA 可显著提升免疫抑制性 IPA 感染小鼠的中位生存时间，提升 21 天存活率，使肺部真菌负荷最高降低 7.64 log10 分生孢子当量/g[2]。
Fosmanogepix (104-260 mg/kg；腹腔注射；每日三次/两次；7 天) TFA 在小鼠模型中对耳念珠菌侵袭性念珠菌病具有保护作用[3]。
Fosmanogepix (52-104 mg/kg；口服；每日一次；7 天) TFA 可显著提升由 Rhizopus arrhizus var. delemar 99-880 引起肺毛霉病的中性粒细胞减少小鼠的存活率[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 (male; infected with 5.9 x 104 CFU *C. neoformans* strain H99 via lateral tail vein injection)[1]
Dosage: 390 mg/kg
Administration: p.o.; three times daily; 7 days
Result: Reduced brain fungal burden by 0.78 log10 CFU/g relative to untreated controls.
Reduced lung fungal burden by 1.50 log10 CFU/g relative to untreated controls.
Achieved statistically significant reduction in lung fungal burden relative to controls.
分子量

582.42

Formula

C24H22F3N4O8P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fosmanogepix TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FosmanogepixFungalGwt1fungal inositol acyltransferasemurine modelsGPI-anchor biosynthesisRhizopus arrhizus var. arrhizusCandida aurisCryptococcus neoformansCryptococcus gattiifungal cell wall integrityRhizopus arrhizus var. delemarInhibitorinhibitorinhibit

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产品名称：
Fosmanogepix TFA
目录号：
HY-119726B
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