2. Gene
  3. Sharpin - SHANK-associated RH domain interacting protein Gene

Sharpin - SHANK-associated RH domain interacting protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: cpdm; SIPL1; RBCKL1; 0610041B22Rik

基因 ID: 106025 | 基因类型: protein coding

关于 Sharpin

功能概要

Predicted to enable several functions, including identical protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Involved in negative regulation of inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB signaling; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Predicted to be located in cytosol; dendrite; and postsynaptic density. Predicted to be part of LUBAC complex. Is expressed in genitourinary system. Used to study atopic dermatitis. Orthologous to human SHARPIN (SHANK associated RH domain interactor). [provided by Alliance of Genome Resources, Apr 2022]

Sharpin 基因产物(1)

mRNA Protein Name
NM_025340.2 NP_079616.2 sharpin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20956555 MGI
enables protein-macromolecule adaptor activity IMP
IMP: 通过突变表型推断
34755089 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic nuclear changes IMP
IMP: 通过突变表型推断
7792947 MGI
acts upstream of or within epidermis development IMP
IMP: 通过突变表型推断
7792947 MGI
acts upstream of or within keratinization IMP
IMP: 通过突变表型推断
7792947 MGI
acts upstream of or within mitochondrion organization IMP
IMP: 通过突变表型推断
7792947 MGI
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
21455173 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
21455173 MGI
involved in regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
21455173 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of LUBAC complex IDA
IDA: 通过直接分析推断
34755089 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sharpin

mSIPL1

protein kinase C-interacting protein RBCC like 1

shank-associated RH domain-interacting protein

shank-interacting protein-like 1

Sharpin 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Sharpin Q91WA6 Eya1 Mus musculus P97767
Pull Down
20956555
种属内
Sharpin Q91WA6 Rnf31 Mus musculus Q924T7
Anti Bait CoIP
21455181
种属内
Sharpin Q91WA6 Rnf31 Mus musculus Q924T7
Anti Bait CoIP
21455180
种属内
Sharpin Q91WA6 Rnf31 Mus musculus Q924T7
Anti Bait CoIP
23942237
种属内
Sharpin Q91WA6 Eya2 Mus musculus O08575
Y2H
20956555
种属内
Sharpin Q91WA6 Eya2 Mus musculus O08575
Pull Down
20956555
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12853 SHARPIN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19284 Sharpin Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25774 Sharpin Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sharpin NCBI NCBI:81858
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