CHP1 - calcineurin like EF-hand protein 1 Gene

中文名称：神经钙蛋白样 EF-手蛋白 1

种属: Homo sapiens

同用名: CHP; p22; p24; SPAX9; Sid470p; SLC9A1BP

基因 ID: 11261 | 基因类型: protein coding

关于 CHP1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,231,268-41,281,887 (from NCBI)

This gene has 9 transcripts (splice variants), 230 orthologues, 8 paralogues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 59.2), liver (RPKM 56.3) and 25 other tissues.

功能概要

该基因编码一种与 Na+/H+ 交换器 NHE1 结合的磷蛋白。该蛋白作为支持 NHE 家族成员生理活性的必需辅助因子，可能在 NHE1 的促有丝分裂调节中发挥作用。该蛋白质与钙调神经磷酸酶 B 和钙调蛋白具有相似性，并且还已知它是钙调神经磷酸酶活性的内源性抑制剂。[RefSeq 提供，2008 年 7 月]

This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with Calcineurin B and Calmodulin and it is also known to be an endogenous inhibitor of Calcineurin activity. [provided by RefSeq, Jul 2008]

CHP1 基因产物(1)

mRNA	Protein	Name
NM_007236.5	NP_009167.1	calcineurin B homologous protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium ion binding	IDA IDA: 通过直接分析推断	15035633	GOA
enables calcium-dependent protein binding	IDA IDA: 通过直接分析推断	15035633	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	8901634	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	10593895	GOA
involved in negative regulation of calcineurin-NFAT signaling cascade	IDA IDA: 通过直接分析推断	10593895	GOA
involved in negative regulation of phosphatase activity	IDA IDA: 通过直接分析推断	10593895	GOA
involved in negative regulation of protein import into nucleus	IDA IDA: 通过直接分析推断	10593895	GOA
involved in positive regulation of phospholipid biosynthetic process	IMP IMP: 通过突变表型推断	30846317	GOA
involved in positive regulation of sodium:proton antiporter activity	IDA IDA: 通过直接分析推断	8901634	GOA
involved in regulation of intracellular pH	IDA IDA: 通过直接分析推断	8901634	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	11350981	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	29379881	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHP1 蛋白结构

EF-hand_7

0
100
195 a.a.

蛋白主名

其他名称

calcineurin B homologous protein 1

EF-hand calcium-binding domain-containing protein p22

CHP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CHP1	Q99653	SLC9A1	Homo sapiens	P19634	Fluorescence	31912575
种属内	CHP1	Q99653	SLC9A1	Homo sapiens	P19634	ITC	31912575
种属内	CHP1	Q99653	SLC9A1	Homo sapiens	P19634	MST	31912575

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spastic Ataxia 9, Autosomal Recessive

SPAX9

Lichtenstein-Knorr Syndrome

Scar19	LIKNS
Autosomal Recessive Spinocerebellar Ataxia 19	Spinocerebellar Ataxia, Autosomal Recessive 19
Progressive Autosomal Recessive Ataxia-Deafness Syndrome	Progressive Autosomal Recessive Ataxia-Sensorineural Hearing Loss Syndrome
Spinocerebellar Ataxia, Autosomal Recessive, 19

Cataract 3, Multiple Types

Cataract 3 Multiple Types	CTRCT3
Cca2	Cataract, Congenital, Cerulean Type, 2
Cataract 3, Multiple Types, With Or Without Microcornea	Cataract 3 Multiple Types With Or Without Microcornea
Congenital Cerulean Type Cataract 2	Congenital Cataract Blue Dot Type 2
Congenital Cataract Cerulean Type 2	Cspc
Sutural Cataract With Punctate And Cerulean Opacities

Spastic Paraparesis

Spastic Ataxia

Spax	Ataxia, Spastic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02652	CHP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21312	Chp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CHP1	MGD	MGI:1927185
Canis familiaris	CHP1	VGNC	VGNC:39227
Bos taurus	CHP1	VGNC	VGNC:27310
Rattus norvegicus	CHP1	RGD	RGD:620447
Felis catus	CHP1	VGNC	VGNC:81003

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CHP1 - calcineurin like EF-hand protein 1 Gene

关于 CHP1

功能概要

CHP1 基因产物(1)

CHP1 蛋白结构

CHP1 蛋白互作信息

关联疾病

直系同源

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CHP1 - calcineurin like EF-hand protein 1 Gene

关于 CHP1

功能概要

CHP1 基因产物(1)

CHP1 蛋白结构

CHP1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z