Brca2 - breast cancer 2, early onset Gene

种属: Mus musculus

同用名: Fancd1; RAB163

关于 Brca2

功能概要

Predicted to enable several functions, including gamma-tubulin binding activity; Histone Acetyltransferase activity; and protein C-terminus binding activity. Involved in several processes, including establishment of protein localization to telomere; male meiosis I; and telomere maintenance via recombination. Acts upstream of or within several processes, including DNA metabolic process; gamete generation; and signal transduction by p53 class mediator. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and hemolymphoid system gland. Used to study Fanconi anemia complementation group D1 and breast Cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain Cancer (multiple); hereditary breast ovarian Cancer syndrome; melanoma (multiple); and reproductive organ Cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]