CCR1 - C-C motif chemokine receptor 1 Gene

中文名称：CC 基序趋化因子受体 1

种属: Homo sapiens

同用名: CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1

基因 ID: 1230 | 基因类型: protein coding

关于 CCR1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,201,711-46,208,313 (from NCBI)

This gene has 1 transcript (splice variant), 159 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in appendix (RPKM 27.8), spleen (RPKM 15.6) and 17 other tissues.

功能概要

该基因编码β趋化因子受体家族的一员，预计是一种类似于 G 蛋白偶联受体的七次跨膜蛋白。该受体的配体包括巨噬细胞炎性蛋白 1 α (MIP-1 α) 、激活正常 T 表达和分泌蛋白 (RANTES) 、单核细胞趋化蛋白 3 (MCP-3) 和骨髓祖细胞抑制因子-1 (MPIF) -1) .趋化因子及其受体介导的信号转导对于将效应免疫细胞募集到炎症部位至关重要。小鼠同系物的敲除研究表明该基因在宿主保护免受炎症反应以及对病毒和寄生虫的易感性中的作用。该基因和其他趋化因子受体基因，包括 CCR2、CCRL2、CCR3、CCR5 和 CCXCR1，被发现在染色体 3p 上形成一个基因簇。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the beta Chemokine Receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and Parasite. This gene and other Chemokine Receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008]

CCR1 基因产物(1)

mRNA	Protein	Name
NM_001295.3	NP_001286.1	C-C chemokine receptor type 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables C-C chemokine binding	IPI IPI: 通过物理相互作用推断	7545673	GOA
enables C-C chemokine receptor activity	IDA IDA: 通过直接分析推断	10734056	GOA
enables chemokine (C-C motif) ligand 5 binding	IPI IPI: 通过物理相互作用推断	7545673	GOA
enables chemokine (C-C motif) ligand 7 binding	IPI IPI: 通过物理相互作用推断	7545673	GOA
enables chemokine receptor activity	IDA IDA: 通过直接分析推断	10660125	GOA
enables phosphatidylinositol phospholipase C activity	IDA IDA: 通过直接分析推断	10734056	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	8699119	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in calcium ion transport	IDA IDA: 通过直接分析推断	10734056	GOA
involved in cell-cell signaling	IDA IDA: 通过直接分析推断	10734056	GOA
involved in chemokine-mediated signaling pathway	IDA IDA: 通过直接分析推断	21403648	GOA
involved in exocytosis	IDA IDA: 通过直接分析推断	10734056	GOA
involved in immune response	IDA IDA: 通过直接分析推断	10734056	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: 通过直接分析推断	10734056	GOA
involved in monocyte chemotaxis	IDA IDA: 通过直接分析推断	29930254	GOA
involved in negative regulation of bone mineralization	IMP IMP: 通过突变表型推断	21403648	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	21403648	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	21403648	GOA
involved in positive regulation of calcium ion transport	IDA IDA: 通过直接分析推断	15764707	GOA
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	24056371	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: 通过直接分析推断	10734056	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: 通过直接分析推断	18587271	GOA
involved in positive regulation of osteoclast differentiation	IMP IMP: 通过突变表型推断	21403648	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	10706735	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	10660125	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	15001559	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCR1 蛋白结构

7tm_1

0
100
200
300
355 a.a.

蛋白主名

其他名称

C-C chemokine receptor type 1

C-C CKR-1	CC-CKR-1
CCR-1	LD78 receptor
MIP-1alpha-R	RANTES receptor
RANTES-R	chemokine (C-C motif) receptor 1
macrophage inflammatory protein 1-alpha receptor

CCR1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCR1	P32246	TMX1	Homo sapiens	Q9H3N1	Y2H Prey Pooling	32296183
种属内	CCR1	P32246	TMX1	Homo sapiens	Q9H3N1	Validated Y2H	32296183
种属内	CCR1	P32246	TMX1	Homo sapiens	Q9H3N1	Y2H Array	32296183
种属内	CCR1	P32246	CCL5	Homo sapiens	P13501	FACS	28381538
种属内	CCR1	P32246	PLP2	Homo sapiens	Q04941	Imaging	15474493
种属内	CCR1	P32246	PLP2	Homo sapiens	Q04941	Anti Tag CoIP	33961781
种属内	CCR1	P32246	CREB3	Homo sapiens	O43889-2	Anti Tag CoIP	15001559
种属内	CCR1	P32246	CREB3	Homo sapiens	O43889-2	IF	15001559
种属内	CCR1	P32246	CREB3	Homo sapiens	O43889-2	Y2H	15001559

种属间: 跨种属相互作用 种属内: 同种属相互作用

CCR1 抗体

目录号	产品名	应用	反应物种
HY-P84260	CD191 Antibody (YA3957)	WB, FC, ELISA	Human

关联疾病

疾病名称

别名

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Chromoblastomycosis

Chromomycosis	Mossy Foot Disease
Verrucous Dermatitis	Fonseca Disease
Pedroso Disease	Drechslera Hawaiiensis
Drechslera Infection

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Corneal Ulcer

Cornea Ulcer	Ulcerative Keratitis
Corneal Ulcer Nos

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-15545	AZD-4818		99.10%	Phase 2
HY-U00350	CCX354	Antagonist	99.18%	Phase 2
HY-120588	BI 639667	Antagonist	98.87%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12080	BX471	Antagonist	99.98%	否
HY-18611A	Abaucin	Antagonist	99.59%	否
HY-12080A	BX471 hydrochloride	Antagonist	99.94%	否
HY-18611	Abaucin hydrochloride	Antagonist	99.90%	否
HY-103360	J-113863	Antagonist	≥99.0%	否
HY-103355	YM022	Antagonist	99.87%	否
HY-P4191A	Met-RANTES (human) acetate	Antagonist	99.39%	否
HY-15546	BMS-817399	Antagonist	99.83%	否
HY-124759	CCR1 antagonist 9	Antagonist	99.65%	否
HY-P4191	Met-RANTES (human)	Antagonist	/	否
HY-124668A	CCR1 antagonist 13	Antagonist	/	否
HY-12079	CP-481715	Antagonist	/	否
HY-15544	CCR1 antagonist 10	Antagonist	/	否
HY-124668	CCR1 antagonist 12	Antagonist	/	否
HY-171476	CP-865569	Antagonist	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CCR1	VGNC	VGNC:102023
Rattus norvegicus	CCR1	RGD	RGD:708446
Mus musculus	CCR1	MGD	MGI:104618
Macaca mulatta	CCR1	VGNC	VGNC:70737
Others	CCR1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
粤ICP备2021105330号-3 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2026 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3