2. Gene
  3. Ldb1 - LIM domain binding 1 Gene

Ldb1 - LIM domain binding 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: NLI; CLIM2

基因 ID: 16825 | 基因类型: protein coding

关于 Ldb1

功能概要

Enables several functions, including LIM domain binding activity; protein homodimerization activity; and protein self-association. Contributes to DNA binding activity. Involved in several processes, including histone H3-K4 acetylation; negative regulation of erythrocyte differentiation; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; epithelial structure maintenance; and hair follicle development. Located in cell leading edge and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; eye; and genitourinary system. Used to study nail-patella syndrome. Orthologous to human LDB1 (LIM domain binding 1). [provided by Alliance of Genome Resources, Apr 2022]

Ldb1 基因产物(5)

mRNA Protein Name
NM_001113408.3 NP_001106879.1 LIM domain-binding protein 1 isoform 1
NM_001360336.2 NP_001347265.1 LIM domain-binding protein 1 isoform 2
NM_001410966.1 NP_001397895.1 LIM domain-binding protein 1 isoform 2
NM_001410967.1 NP_001397896.1 LIM domain-binding protein 1 isoform 3
NM_010697.3 NP_034827.1 LIM domain-binding protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to DNA binding IDA
IDA: 通过直接分析推断
9391090 MGI
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
18539116 MGI
enables LIM domain binding IDA
IDA: 通过直接分析推断
8876198 MGI
enables LIM domain binding IPI
IPI: 通过物理相互作用推断
9192866 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
18550854 MGI
enables enzyme binding IPI
IPI: 通过物理相互作用推断
11882901 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19323994 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8918878 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
9315627 MGI
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
18539116 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Wnt signaling pathway IMP
IMP: 通过突变表型推断
12490556 MGI
acts upstream of or within anterior/posterior axis specification IMP
IMP: 通过突变表型推断
12490556 MGI
acts upstream of cell adhesion IGI
IGI: 通过遗传相互作用推断
17991461 MGI
acts upstream of or within cellular component assembly IGI
IGI: 通过遗传相互作用推断
17991461 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IMP
IMP: 通过突变表型推断
17664423 MGI
acts upstream of or within cerebellum development IMP
IMP: 通过突变表型推断
17664423 MGI
acts upstream of or within epithelial structure maintenance IGI
IGI: 通过遗传相互作用推断
17991461 MGI
acts upstream of or within gastrulation with mouth forming second IMP
IMP: 通过突变表型推断
12490556 MGI
acts upstream of or within hair follicle development IGI
IGI: 通过遗传相互作用推断
17991461 MGI
involved in head development IGI
IGI: 通过遗传相互作用推断
15857913 MGI
involved in negative regulation of erythrocyte differentiation IMP
IMP: 通过突变表型推断
9391090 MGI
involved in neuron differentiation IEP
IEP: 通过表达模式推断
8876198 MGI
acts upstream of or within positive regulation of cell adhesion IGI
IGI: 通过遗传相互作用推断
17991461 MGI
involved in positive regulation of hemoglobin biosynthetic process IMP
IMP: 通过突变表型推断
20570862 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
9192866 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9192866 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18539116 MGI
involved in positive regulation of transcription elongation by RNA polymerase II IMP
IMP: 通过突变表型推断
20570862 MGI
involved in regulation of cell migration IDA
IDA: 通过直接分析推断
19675209 MGI
involved in regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
19675209 MGI
involved in regulation of kinase activity IDA
IDA: 通过直接分析推断
19675209 MGI
acts upstream of or within somatic stem cell population maintenance IGI
IGI: 通过遗传相互作用推断
17991461 MGI
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15857913 MGI
involved in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IMP
IMP: 通过突变表型推断
20570862 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
9860983 MGI
located in cell leading edge IDA
IDA: 通过直接分析推断
19675209 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8876198 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
15857913 MGI
part of protein-containing complex IPI
IPI: 通过物理相互作用推断
9391090 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
19323994 MGI
part of transcription regulator complex IMP
IMP: 通过突变表型推断
18539116 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

LIM domain-binding protein 1

LIM domain-binding factor CLIM2

carboxyl-terminal LIM domain-binding protein 2

nuclear LIM interactor

Ldb1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ldb1 P70662 Tcf4 Mus musculus Q60722
Anti Bait CoIP
16407974
种属内
Ldb1 P70662 Isl1 Mus musculus P61372
Y2H
18583962
种属内
Ldb1 P70662 Lhx3 Mus musculus P50481
Y2H
18583962
种属内
Ldb1 P70662 Tal1 Mus musculus P22091
Anti Bait CoIP
16407974
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07568 LDB1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07569 LDB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19348 Ldb1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25839 Ldb1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ldb1 NCBI NCBI:8861
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