Mitf - melanogenesis associated transcription factor Gene

种属: Mus musculus

同用名: Wh; bw; mi; vit; BCC2; Bhlhe32; Gsfbcc2; Vitiligo

基因 ID: 17342 | 基因类型: protein coding

关于 Mitf

功能概要

This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008]

Mitf 基因产物(12)

mRNA	Protein	Name
NM_001113198.2	NP_001106669.1	microphthalmia-associated transcription factor isoform 1
NM_001178049.2	NP_001171520.1	microphthalmia-associated transcription factor isoform 3
NM_001410051.1	NP_001396980.1	microphthalmia-associated transcription factor isoform 4
NM_001410052.1	NP_001396981.1	microphthalmia-associated transcription factor isoform 5
NM_001410053.1	NP_001396982.1	microphthalmia-associated transcription factor isoform 6
NM_001410054.1	NP_001396983.1	microphthalmia-associated transcription factor isoform 7
NM_001410055.1	NP_001396984.1	microphthalmia-associated transcription factor isoform 8
NM_001410056.1	NP_001396985.1	microphthalmia-associated transcription factor isoform 9
NM_001410057.1	NP_001396986.1	microphthalmia-associated transcription factor isoform 10
NM_001410058.1	NP_001396987.1	microphthalmia-associated transcription factor isoform 11
NM_001410059.1	NP_001396988.1	microphthalmia-associated transcription factor isoform 12 precursor
NM_008601.4	NP_032627.1	microphthalmia-associated transcription factor isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	14575687	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	15716956	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	12235125	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	15729346	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	23207919	MGI
enables E-box binding	IDA IDA: 通过直接分析推断	23207919	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	15716956	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	15729346	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	17442941	MGI
enables protein dimerization activity	IPI IPI: 通过物理相互作用推断	23207919	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within Wnt signaling pathway	IDA IDA: 通过直接分析推断	12235125	MGI
acts upstream of or within bone remodeling	IMP IMP: 通过突变表型推断	12086670	MGI
acts upstream of or within camera-type eye development	IGI IGI: 通过遗传相互作用推断	15576400	MGI
acts upstream of or within cell differentiation	IMP IMP: 通过突变表型推断	9199364	MGI
acts upstream of or within cell fate commitment	IMP IMP: 通过突变表型推断	15576400	MGI
acts upstream of melanocyte apoptotic process	IMP IMP: 通过突变表型推断	12086670	MGI
acts upstream of or within melanocyte differentiation	IGI IGI: 通过遗传相互作用推断	12086670	MGI
acts upstream of or within melanocyte differentiation	IMP IMP: 通过突变表型推断	2379821	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	12086670	MGI
acts upstream of or within osteoclast differentiation	IMP IMP: 通过突变表型推断	12086670	MGI
acts upstream of or within pigmentation	IGI IGI: 通过遗传相互作用推断	12086670	MGI
acts upstream of or within pigmentation	IMP IMP: 通过突变表型推断	2379821	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	14575687	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17442941	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15304486	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	15729346	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	24769727	MGI
acts upstream of or within regulation of cell population proliferation	IDA IDA: 通过直接分析推断	12235125	MGI
acts upstream of or within regulation of gene expression	IMP IMP: 通过突变表型推断	12086670	MGI
acts upstream of or within regulation of osteoclast differentiation	IGI IGI: 通过遗传相互作用推断	11930005	MGI
acts upstream of or within regulation of osteoclast differentiation	IMP IMP: 通过突变表型推断	11930005	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12235125	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23207919	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	12235125	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

microphthalmia-associated transcription factor

black eyed white

microphtalmia-associated transcription factor

目录号	产品名	作用方式	纯度	Phase
HY-113337	Ap4A	Inducer	/	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101464	ML329	Inhibitor	98.0%	否
HY-156483	TT-012		99.76%	否
HY-113337A	Ap4A tetraammonium	Inducer	99.98%	否
HY-D0168	Orcinol		99.97%	否
HY-N1481	Methyl linoleate	Inhibitor	98.0%	否
HY-N2983	Cajanin	Inhibitor	99.96%	否
HY-N12267	N,N′-Diferuloylputrescine	Inhibitor	97.0%	否
HY-N2204	Swertiajaponin	Inhibitor	99.84%	否
HY-169363	PDL1 degrader-2		99.41%	否
HY-N10016	Chlorogenic acid butyl ester	Inhibitor	98.19%	否
HY-179717	WZS0347	Degrader	/	否
HY-N6901	Luteolin 7-sulfate		≥95.0%	否
HY-RS16290	Mitf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS08467	MITF Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-159917	PPL agonist-1		/	否
HY-179718	TT-012-Br	Degrader	/	否
HY-179720	TT-012-NH-C7-NHBoc		/	否
HY-N0113A	Hordenine sulfate		/	否
HY-N10437	6-Acetylnimbandiol	Inhibitor	/	否
HY-N3810	ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Inhibitor	/	否
HY-P4497	Prolylserine	Inhibitor	/	否
HY-157010	AP736	Inhibitor	/	否
HY-174580	Human MITF mRNA		/	否
HY-N10623	5-epi-Arvestonate A	Activator	/	否
HY-RS17594	Tff3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23266	Mitf Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Mitf	NCBI	NCBI:4286

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
粤ICP备2021105330号-3 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2026 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3