DUSP9 - dual specificity phosphatase 9 Gene

中文名称：双特异性磷酸酶 9

种属: Homo sapiens

同用名: MKP4; MKP-4

关于 DUSP9

功能概要

该基因编码的蛋白质是双特异性蛋白磷酸酶亚家族的成员。这些磷酸酶通过使磷酸丝氨酸/苏氨酸和磷酸酪氨酸残基去磷酸化来灭活它们的靶激酶。它们负向调节与细胞增殖和分化相关的丝裂原活化蛋白 (MAP) 激酶超家族成员 (MAPK/ERK、SAPK/JNK、p38) 。双特异性磷酸酶家族的不同成员对各种 MAP 激酶表现出不同的底物特异性、不同的组织分布和亚细胞定位，以及细胞外刺激表达的不同诱导模式。该基因产物显示出对 MAP 激酶 ERK 家族成员的选择性，并定位于细胞质和细胞核。该基因的异常表达与 2 型糖尿病和几种细胞类型的癌症进展有关。交替剪接导致多个转录本变体。[RefSeq 提供，2016 年 1 月]

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and Cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]