2. Gene
  3. Pip5k1c - phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma Gene

Pip5k1c - phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Pip5kIgamma

基因 ID: 18717 | 基因类型: protein coding

关于 Pip5k1c

功能概要

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and talin binding activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization and regulation of synaptic vesicle endocytosis. Acts upstream of or within axonogenesis; phosphatidylinositol biosynthetic process; and platelet aggregation. Located in cytosol and postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Orthologous to human PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Pip5k1c 基因产物(4)

mRNA Protein Name
NM_001146687.2 NP_001140159.1 phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 2
NM_001293646.1 NP_001280575.1 phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 3
NM_001293647.1 NP_001280576.1 phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 4
NM_008844.3 NP_032870.2 phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
IDA: 通过直接分析推断
9535851 MGI
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
IMP: 通过突变表型推断
20622009 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17290217 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within axonogenesis IDA
IDA: 通过直接分析推断
14741049 MGI
acts upstream of or within phosphatidylinositol biosynthetic process IDA
IDA: 通过直接分析推断
20622009 MGI
acts upstream of or within phosphatidylinositol biosynthetic process IMP
IMP: 通过突变表型推断
20622009 MGI
acts upstream of or within phosphatidylinositol metabolic process IDA
IDA: 通过直接分析推断
9535851 MGI
acts upstream of or within platelet aggregation IMP
IMP: 通过突变表型推断
23372168 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
22243752 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: 通过表达模式推断
22243752 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
22243752 MGI
involved in regulation of synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
15386003 MGI
involved in regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
15386003 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
20622009 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
22243752 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
22243752 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
22243752 MGI
is active in postsynaptic density IDA
IDA: 通过直接分析推断
22243752 MGI
is active in postsynaptic density IEP
IEP: 通过表达模式推断
22243752 MGI
is active in postsynaptic density IMP
IMP: 通过突变表型推断
22243752 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

PIP5K1-gamma

phosphatidylinositol 4-phosphate 5-kinase type I gamma

ptdIns(4)P-5-kinase 1 gamma

Pip5k1c 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Pip5k1c O70161 Ap2b1 Mus musculus Q9DBG3-2
Pull Down
17290217
种属内
Pip5k1c O70161 Ap2b1 Mus musculus Q9DBG3-2
Anti Bait CoIP
17290217
种属内
Pip5k1c O70161 Ap2b1 Mus musculus Q9DBG3-2
Anti Tag CoIP
17290217
种属内
Pip5k1c O70161 Ap2b1 Mus musculus Q9DBG3-1
Protein Kinase Assay
17290217
种属内
Pip5k1c O70161 Ap2b1 Mus musculus Q9DBG3-1
Anti Tag CoIP
17290217
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110150 UNC3230 Inhibitor 99.39% 否
HY-148907 CS640 Inhibitor 96.13% 否
HY-163476 PIP5K1C-IN-1 Inhibitor 98.71% 否
HY-163943 UNI418 Inhibitor 99.61% 否
HY-163477 PIP5K1C-IN-2 Inhibitor / 否
HY-E70633 PIP5K1C Recombinant Human Active Lipid Kinase / 否
HY-RS10568 PIP5K1C Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19283 Pip5k1c Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25773 Pip5k1c Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pip5k1c NCBI NCBI:23396
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