Foxp3 - forkhead box P3 Gene

种属: Mus musculus

同用名: sf; JM2; scurfin

基因 ID: 20371 | 基因类型: protein coding

关于 Foxp3

功能概要

The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Foxp3 基因产物(3)

mRNA	Protein	Name
NM_001199347.1	NP_001186276.1	forkhead box protein P3
NM_001199348.1	NP_001186277.1	forkhead box protein P3
NM_054039.2	NP_473380.1	forkhead box protein P3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	17028180	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	17028180	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	17377532	MGI
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16769892	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	17377532	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	17028180	MGI
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	15790681	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within B cell homeostasis	IMP IMP: 通过突变表型推断	10072494	MGI
acts upstream of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of CD4-positive, alpha-beta T cell differentiation	IDA IDA: 通过直接分析推断	17028180	MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation	IDA IDA: 通过直接分析推断	17028180	MGI
acts upstream of DNA-templated transcription	IDA IDA: 通过直接分析推断	17028180	MGI
acts upstream of or within T cell activation	IMP IMP: 通过突变表型推断	10072494	MGI
acts upstream of T cell anergy	IMP IMP: 通过突变表型推断	16945588	MGI
acts upstream of or within T cell mediated immunity	IMP IMP: 通过突变表型推断	11714795	MGI
acts upstream of T cell proliferation	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of T cell proliferation	IMP IMP: 通过突变表型推断	16203996	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: 通过突变表型推断	10072494	MGI
acts upstream of T cell tolerance induction	IMP IMP: 通过突变表型推断	16945588	MGI
acts upstream of alpha-beta T cell proliferation	IMP IMP: 通过突变表型推断	16945588	MGI
acts upstream of or within chromatin remodeling	IDA IDA: 通过直接分析推断	17028180	MGI
acts upstream of or within cytokine production	IDA IDA: 通过直接分析推断	15790681	MGI
acts upstream of or within cytokine production	IGI IGI: 通过遗传相互作用推断	7930593	MGI
acts upstream of or within cytokine production	IMP IMP: 通过突变表型推断	7930593	MGI
acts upstream of or within gene expression	IMP IMP: 通过突变表型推断	28396406	MGI
acts upstream of immature T cell proliferation in thymus	IMP IMP: 通过突变表型推断	16230479	MGI
acts upstream of inflammatory response	IMP IMP: 通过突变表型推断	16203996	MGI
acts upstream of interleukin-10 production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of interleukin-2 production	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of interleukin-4 production	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of interleukin-4 production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of interleukin-5 production	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of interleukin-5 production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of interleukin-6 production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of isotype switching to IgE isotypes	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of lymphocyte proliferation	IMP IMP: 通过突变表型推断	16227984	MGI
acts upstream of or within myeloid cell homeostasis	IMP IMP: 通过突变表型推断	10072494	MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: 通过直接分析推断	17028180	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15100250	MGI
acts upstream of or within negative regulation of T cell proliferation	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: 通过突变表型推断	16203996	MGI
acts upstream of or within negative regulation of alpha-beta T cell proliferation	IMP IMP: 通过突变表型推断	16945588	MGI
acts upstream of or within negative regulation of chronic inflammatory response	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of or within negative regulation of chronic inflammatory response	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: 通过直接分析推断	24501220	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: 通过突变表型推断	16203996	MGI
acts upstream of or within negative regulation of interleukin-10 production	IMP IMP: 通过突变表型推断	16275384	MGI
involved in negative regulation of interleukin-17 production	IMP IMP: 通过突变表型推断	18368049	MGI
acts upstream of or within negative regulation of interleukin-2 production	IDA IDA: 通过直接分析推断	16769892	MGI
involved in negative regulation of interleukin-2 production	IDA IDA: 通过直接分析推断	17377532	MGI
involved in negative regulation of interleukin-2 production	IMP IMP: 通过突变表型推断	18368049	MGI
acts upstream of or within negative regulation of interleukin-4 production	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of or within negative regulation of interleukin-4 production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of or within negative regulation of interleukin-5 production	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of or within negative regulation of interleukin-5 production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of or within negative regulation of interleukin-6 production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of or within negative regulation of isotype switching to IgE isotypes	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of or within negative regulation of lymphocyte proliferation	IMP IMP: 通过突变表型推断	16227984	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16230479	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16230479	MGI
acts upstream of or within negative regulation of tumor necrosis factor production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of or within negative regulation of type II interferon production	IDA IDA: 通过直接分析推断	16769892	MGI
involved in negative regulation of type II interferon production	IDA IDA: 通过直接分析推断	17377532	MGI
acts upstream of or within negative regulation of type II interferon production	IMP IMP: 通过突变表型推断	16275384	MGI
involved in negative regulation of type II interferon production	IMP IMP: 通过突变表型推断	18368049	MGI
acts upstream of or within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: 通过突变表型推断	12612578	MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell differentiation	IDA IDA: 通过直接分析推断	17028180	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	17028180	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	17377532	MGI
acts upstream of or within positive regulation of T cell anergy	IMP IMP: 通过突变表型推断	16945588	MGI
acts upstream of or within positive regulation of T cell tolerance induction	IMP IMP: 通过突变表型推断	16945588	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: 通过直接分析推断	20706986	MGI
acts upstream of or within positive regulation of immature T cell proliferation in thymus	IMP IMP: 通过突变表型推断	16230479	MGI
acts upstream of or within positive regulation of interleukin-4 production	IMP IMP: 通过突变表型推断	20944002	MGI
acts upstream of or within positive regulation of peripheral T cell tolerance induction	IMP IMP: 通过突变表型推断	16532000	MGI
acts upstream of or within positive regulation of regulatory T cell differentiation	IDA IDA: 通过直接分析推断	12522256	MGI
acts upstream of or within positive regulation of regulatory T cell differentiation	IMP IMP: 通过突变表型推断	15780990	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17028180	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16945588	MGI
acts upstream of or within positive regulation of transforming growth factor beta1 production	IDA IDA: 通过直接分析推断	17028180	MGI
involved in regulation of T cell anergy	IMP IMP: 通过突变表型推断	17377532	MGI
acts upstream of or within regulation of immunoglobulin production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of or within regulation of isotype switching to IgG isotypes	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	18997793	MGI
acts upstream of regulatory T cell differentiation	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of or within tolerance induction	IDA IDA: 通过直接分析推断	15809349	MGI
acts upstream of or within tolerance induction to self antigen	IMP IMP: 通过突变表型推断	15780990	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17028180	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16945588	MGI
acts upstream of transforming growth factor beta1 production	IDA IDA: 通过直接分析推断	17028180	MGI
acts upstream of tumor necrosis factor production	IMP IMP: 通过突变表型推断	16275384	MGI
acts upstream of type II interferon production	IDA IDA: 通过直接分析推断	16769892	MGI
acts upstream of type II interferon production	IMP IMP: 通过突变表型推断	16275384	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17028180	MGI
located in intracellular anatomical structure	IDA IDA: 通过直接分析推断	19015308	MGI
located in nucleus	IDA IDA: 通过直接分析推断	16769892	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

forkhead box protein P3

scurfy

Foxp3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Foxp3	Q99JB6	Usp44	Mus musculus	Q8C2S0	Confocal	32644293
种属内	Foxp3	Q99JB6	Runx1	Mus musculus	Q03347	Pull Down	17377532
种属内	Foxp3	Q99JB6	Runx1	Mus musculus	Q03347	Anti Tag CoIP	17377532

种属间: 跨种属相互作用 种属内: 同种属相互作用

目录号	产品名	作用方式	纯度	是否罕见病
HY-13624A	Epirubicin hydrochloride		99.62%	是
HY-13624	Epirubicin		99.11%	是

目录号	产品名	作用方式	纯度	Phase
HY-160040A	Cobitolimod sodium	Agonist	/	Phase 3
HY-148808	Zelasudil	Inhibitor	99.33%	Phase 2

目录号	产品名	作用方式	纯度	Phase
HY-P991180	TRX-518	Ligand	98.58%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-126675A	AS2863619		98.02%	否
HY-P1684	Peptide P60	Inhibitor	98.39%	否
HY-124131	DS-437	Inhibitor	99.22%	否
HY-126675	AS2863619 free base		99.87%	否
HY-P1453A	CMD178 TFA	Inhibitor	99.71%	否
HY-W107024	BMS-986260	Inhibitor	99.95%	否
HY-RS05075	FOXP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-162946	Alkyne-P60		99.95%	否
HY-159692A	AZD8701 sodium	Inhibitor	/	否
HY-162943	P60-L3-VHL		99.84%	否
HY-15091	Anisperimus		/	否
HY-159692	AZD8701	Inhibitor	/	否
HY-160040	Cobitolimod	Agonist	/	否
HY-162600	CDK8-IN-15	Inhibitor	/	否
HY-N16465	Cinnamtannin D1	Inhibitor	/	否
HY-P10808	RSRGVFF	Inhibitor	/	否
HY-P11011	Peptide R54	Antagonist	/	否
HY-RS16899	Foxp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23341	Foxp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-P1453	CMD178	Inhibitor	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990819	Anti-Rat CD28 Antibody (JJ316)	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Foxp3	NCBI	NCBI:50943

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