2. Gene
  3. Git1 - GIT ArfGAP 1 Gene

Git1 - GIT ArfGAP 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Cat-1; p95Cat

基因 ID: 216963 | 基因类型: protein coding

关于 Git1

功能概要

Predicted to enable several functions, including GTPase activator activity; gamma-tubulin binding activity; and small GTPase binding activity. Predicted to be a structural constituent of postsynaptic specialization. Involved in several processes, including cell redox homeostasis; modulation of chemical synaptic transmission; and nervous system development. Acts upstream of or within Ephrin Receptor signaling pathway. Located in calyx of Held and postsynapse. Is expressed in embryo. Used to study attention deficit hyperactivity disorder. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]

Git1 基因产物(2)

mRNA Protein Name
NM_001004144.1 NP_001004144.1 ARF GTPase-activating protein GIT1 isoform 1
NM_001374758.1 NP_001361687.1 ARF GTPase-activating protein GIT1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10428811 MGI
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
17310244 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in brain development IMP
IMP: 通过突变表型推断
25792865 MGI
involved in cell redox homeostasis IMP
IMP: 通过突变表型推断
32460388 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
32460388 MGI
acts upstream of or within ephrin receptor signaling pathway IDA
IDA: 通过直接分析推断
17310244 MGI
involved in intramembranous ossification IMP
IMP: 通过突变表型推断
32460388 MGI
involved in locomotory behavior IMP
IMP: 通过突变表型推断
25792865 MGI
involved in motor learning IMP
IMP: 通过突变表型推断
25792865 MGI
involved in negative regulation of glycolytic process IMP
IMP: 通过突变表型推断
32460388 MGI
involved in negative regulation of inflammatory response to wounding IMP
IMP: 通过突变表型推断
32460388 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
32460388 MGI
involved in neuron development IMP
IMP: 通过突变表型推断
25792865 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
26637799 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
26637799 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
26637799 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
26637799 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in calyx of Held IDA
IDA: 通过直接分析推断
26637799 MGI
is active in calyx of Held IMP
IMP: 通过突变表型推断
26637799 MGI
located in postsynapse IDA
IDA: 通过直接分析推断
24297929 MGI
is active in presynapse IDA
IDA: 通过直接分析推断
26637799 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ARF GTPase-activating protein GIT1

ARF GAP GIT1

G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

G protein-coupled receptor kinase-interactor 1

GRK-interacting protein 1

Git1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Git1 Q68FF6 Arhgef7 Mus musculus Q9ES28
Anti Bait CoIP
16959763
种属内
Git1 Q68FF6 Arhgef7 Mus musculus Q9ES28
Anti Bait CoIP
19022416
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% 否
HY-RS05438 GIT1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19605 Git1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26101 Git1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Git1 NCBI NCBI:28964
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