2. Gene
  3. USP33 - ubiquitin specific peptidase 33 Gene

USP33 - ubiquitin specific peptidase 33 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 33

种属: Homo sapiens

同用名: VDU1

基因 ID: 23032 | 基因类型: protein coding

关于 USP33

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,695,987-77,759,852 (from NCBI)

This gene has 18 transcripts (splice variants), 211 orthologues and 71 paralogues. Ubiquitous expression in fat (RPKM 19.0), brain (RPKM 15.9) and 25 other tissues.

功能概要

该基因编码一种在多种过程中都很重要的去泛素化酶，包括 Slit 依赖性细胞迁移和 β2 肾上腺素能受体信号转导。该蛋白通过 von Hippel-Lindau 肿瘤蛋白 (VHL) 的泛素化负调控。可变剪接导致多种转录本变体和蛋白质同种型。[RefSeq 提供，2012 年 6 月]

This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 Adrenergic Receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

USP33 基因产物(13)

mRNA Protein Name
NM_001377430.1 NP_001364359.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 4
NM_001377431.1 NP_001364360.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 5
NM_001377432.1 NP_001364361.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 6
NM_001377433.1 NP_001364362.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 7
NM_001377434.1 NP_001364363.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 8
NM_001377435.1 NP_001364364.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 9
NM_001377436.1 NP_001364365.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 10
NM_001377437.1 NP_001364366.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 11
NM_001377438.1 NP_001364367.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 12
NM_001377439.1 NP_001364368.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 12
NM_015017.5 NP_055832.3 ubiquitin carboxyl-terminal hydrolase 33 isoform 1
NM_201624.3 NP_963918.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 2
NM_201626.3 NP_963920.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor binding IPI
IPI: 通过物理相互作用推断
19424180 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
23486064 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: 通过突变表型推断
24056301 GOA
enables cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
19363159 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11739384 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
24056301 GOA
NOT enables ubiquitin binding IDA
IDA: 通过直接分析推断
17766394 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
17766394 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to starvation IDA
IDA: 通过直接分析推断
24056301 GOA
involved in centrosome duplication IMP
IMP: 通过突变表型推断
23486064 GOA
involved in negative regulation of protein binding IMP
IMP: 通过突变表型推断
24056301 GOA
involved in positive regulation of protein binding IMP
IMP: 通过突变表型推断
24056301 GOA
involved in protein K48-linked deubiquitination IDA
IDA: 通过直接分析推断
19363159 GOA
involved in protein K63-linked deubiquitination IDA
IDA: 通过直接分析推断
19363159 GOA
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
11739384 GOA
involved in protein deubiquitination IMP
IMP: 通过突变表型推断
24056301 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
23486064 GOA
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
19363159 GOA
involved in regulation of autophagy IMP
IMP: 通过突变表型推断
24056301 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
21801292 GOA
located in centrosome IDA
IDA: 通过直接分析推断
23486064 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
24056301 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP33 蛋白结构

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (61 - 122)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (184 - 712)

DUSP

DUSP: DUSP domain (847 - 916)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 942 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 33

VHL-interacting deubiquitinating enzyme 1

USP33 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
USP33 Q8TEY7 EGFR Homo sapiens P00533
Ub Reconstruction
27956147
种属内
USP33 Q8TEY7 EGFR Homo sapiens P00533
Anti Tag CoIP
27956147
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15544 USP33 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19751 Usp33 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26248 Usp33 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus USP33 VGNC VGNC:66879
Rattus norvegicus USP33 RGD RGD:1307848
Bos taurus USP33 VGNC VGNC:36723
Canis familiaris USP33 VGNC VGNC:48189
Macaca mulatta USP33 VGNC VGNC:79217
Mus musculus USP33 MGD MGI:2159711
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