DAPK2 - death associated protein kinase 2 Gene

中文名称：死亡相关蛋白激酶 2

种属: Homo sapiens

同用名: DRP1; DRP-1

基因 ID: 23604 | 基因类型: protein coding

关于 DAPK2

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:63,907,036-64,046,485 (from NCBI)

This gene has 13 transcripts (splice variants), 202 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues.

功能概要

该基因编码一种属于丝氨酸/苏氨酸蛋白激酶家族的蛋白质。该蛋白质包含一个 N 末端蛋白激酶结构域，后跟一个保守的钙调蛋白结合结构域，与死亡相关蛋白激酶 1 (DAPK1) 具有显着相似性，DAPK1 是程序性细胞死亡的正调节因子。该基因的过表达显示诱导细胞凋亡。它使用多个聚腺苷酸化位点。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell Apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

DAPK2 基因产物(20)

mRNA	Protein	Name
NM_001363730.2	NP_001350659.1	death-associated protein kinase 2 isoform 2
NM_001384997.1	NP_001371926.1	death-associated protein kinase 2 isoform 3
NM_001384998.1	NP_001371927.1	death-associated protein kinase 2 isoform 4
NM_001384999.1	NP_001371928.1	death-associated protein kinase 2 isoform 5
NM_001385000.1	NP_001371929.1	death-associated protein kinase 2 isoform 6
NM_001395279.1	NP_001382208.1	death-associated protein kinase 2 isoform 7
NM_001395281.1	NP_001382210.1	death-associated protein kinase 2 isoform 8
NM_001395282.1	NP_001382211.1	death-associated protein kinase 2 isoform 4
NM_001395283.1	NP_001382212.1	death-associated protein kinase 2 isoform 8
NM_001395284.1	NP_001382213.1	death-associated protein kinase 2 isoform 9
NM_001395285.1	NP_001382214.1	death-associated protein kinase 2 isoform 10
NM_001395286.1	NP_001382215.1	death-associated protein kinase 2 isoform 11
NM_001395287.1	NP_001382216.1	death-associated protein kinase 2 isoform 11
NM_001395288.1	NP_001382217.1	death-associated protein kinase 2 isoform 12
NM_001395289.1	NP_001382218.1	death-associated protein kinase 2 isoform 9
NM_001395290.1	NP_001382219.1	death-associated protein kinase 2 isoform 13 precursor
NM_001395291.1	NP_001382220.1	death-associated protein kinase 2 isoform 14
NM_001395292.1	NP_001382221.1	death-associated protein kinase 2 isoform 9
NM_001395293.1	NP_001382222.1	death-associated protein kinase 2 isoform 15
NM_014326.5	NP_055141.2	death-associated protein kinase 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	10376525	GOA
enables calmodulin binding	IDA IDA: 通过直接分析推断	10376525	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	10629061	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21408167	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in anoikis	IMP IMP: 通过突变表型推断	18957423	GOA
involved in intracellular signal transduction	IDA IDA: 通过直接分析推断	10376525	GOA
involved in positive regulation of eosinophil chemotaxis	IMP IMP: 通过突变表型推断	24163421	GOA
involved in positive regulation of neutrophil chemotaxis	IMP IMP: 通过突变表型推断	24163421	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	10376525	GOA
involved in regulation of intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	10376525	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10376525	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DAPK2 蛋白结构

Pkinase

0
100
200
300
370 a.a.

蛋白主名

其他名称

death-associated protein kinase 2

DAP kinase 2

DAPK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DAPK2	Q9UIK4	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
种属内	DAPK2	Q9UIK4	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	31515488
种属内	DAPK2	Q9UIK4	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
种属内	DAPK2	Q9UIK4	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
种属内	DAPK2	Q9UIK4	CCDC91	Homo sapiens	Q7Z6B0-2	Y2H Prey Pooling	32296183
种属内	DAPK2	Q9UIK4	CCDC91	Homo sapiens	Q7Z6B0-2	Y2H Array	32296183
种属内	DAPK2	Q9UIK4	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	DAPK2	Q9UIK4	DAPK2	Homo sapiens	Q9UIK4	GMS	11230133
种属内	DAPK2	Q9UIK4	DAPK2	Homo sapiens	Q9UIK4	Anti Tag CoIP	10629061

种属间: 跨种属相互作用 种属内: 同种属相互作用

DAPK2 抗体

目录号	产品名	应用	反应物种
HY-P82898	DAPK2 Antibody (YA2643)	WB, IHC-P	Rat
HY-P82898A	DAPK2 Antibody (YA2643)(PBS only)	WB, IHC-P	Rat

关联疾病

疾病名称

别名

Charcot-Marie-Tooth Disease Type 2a2b

Severe Early-Onset Axonal Neuropathy Due To Mfn2 Deficiency	Ar-Cmt2, Ouvrier Type
Autosomal Recessive Charcot-Marie-Tooth Disease, Ouvrier Type	Seoan Due To Mfn2 Deficiency
Charcot-Marie-Tooth Disease, Axonal, Type 2a2b	Cmt2a2b
Charcot-Marie-Tooth Disease, Type 2a2b

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-178967	DRAK1/2-IN-2	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	DAPK2	VGNC	VGNC:55109
Felis catus	DAPK2	VGNC	VGNC:80992
Macaca mulatta	DAPK2	VGNC	VGNC:71733
Mus musculus	DAPK2	MGD	MGI:1341297
Canis familiaris	DAPK2	VGNC	VGNC:59108
Rattus norvegicus	DAPK2	RGD	RGD:1304708
Others	DAPK2	NCBI

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