2. Gene
  3. Nqo1 - NAD(P)H quinone dehydrogenase 1 Gene

Nqo1 - NAD(P)H quinone dehydrogenase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Dia4

基因 ID: 24314 | 基因类型: protein coding

关于 Nqo1

功能概要

Enables NAD(P)H dehydrogenase (quinone) activity and superoxide dismutase activity. Involved in several processes, including NADPH oxidation; regulation of apoptotic process; and response to ischemia. Located in cytosol; dendrite; and neuronal cell body. Used to study several diseases, including chronic kidney disease; colon cancer; hypertension; liver cirrhosis; and membranous glomerulonephritis. Biomarker of several diseases, including brain disease (multiple); chronic obstructive pulmonary disease; fatty liver disease (multiple); prostatitis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including asthma; hematologic Cancer (multiple); lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nqo1 基因产物(2)

mRNA Protein Name
NM_017000.3 NP_058696.2 NAD(P)H dehydrogenase [quinone] 1
NM_017000.3 NP_058696.2 NAD(P)H dehydrogenase [quinone] 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD(P)H dehydrogenase (quinone) activity IDA
IDA: 通过直接分析推断
12603827 RGD
enables NADH:ubiquinone reductase (non-electrogenic) activity IDA
IDA: 通过直接分析推断
8999809 RGD
enables superoxide dismutase activity IMP
IMP: 通过突变表型推断
17901563 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NADH oxidation IDA
IDA: 通过直接分析推断
29389585 RGD
involved in NADPH oxidation IDA
IDA: 通过直接分析推断
29444417 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: 通过直接分析推断
28271112 RGD
involved in cellular response to metal ion IEP
IEP: 通过表达模式推断
28722058 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
22227174 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
12603827 RGD
involved in response to L-glutamine IDA
IDA: 通过直接分析推断
30967905 RGD
involved in response to alkaloid IEP
IEP: 通过表达模式推断
31432116 RGD
involved in response to amine IDA
IDA: 通过直接分析推断
29444417 RGD
involved in response to carbohydrate IEP
IEP: 通过表达模式推断
31933629 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
28887183 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
14672740 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
20833713 RGD
involved in response to flavonoid IEP
IEP: 通过表达模式推断
31399183 RGD
involved in response to hormone IEP
IEP: 通过表达模式推断
30483575 RGD
involved in response to hydrogen sulfide IEP
IEP: 通过表达模式推断
29054567 RGD
involved in response to ischemia IEP
IEP: 通过表达模式推断
31399183 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
21092375 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
21549141 RGD
involved in response to oxidative stress IEP
IEP: 通过表达模式推断
12011483 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
31819135 RGD
involved in response to tetrachloromethane IEP
IEP: 通过表达模式推断
30483575 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
30967905 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
29091898 RGD
involved in superoxide metabolic process IMP
IMP: 通过突变表型推断
17901563 RGD
involved in vitamin K metabolic process IDA
IDA: 通过直接分析推断
8999809 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
28322084 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
14991562 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

NAD(P)H dehydrogenase [quinone] 1

DT-diaphorase

DTD

Diaphorase (NADH/NADPH)

NAD(P)H dehydrogenase, quinone 1

NAD(P)H:menadione oxidoreductase

NAD(P)H:quinone oxidoreductase 1

QR1

azoreductase

menadione reductase

phylloquinone reductase

quinone reductase 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-181017 Ola-NC-SS-PEG-Lap / 否
HY-180155 Keap1/Nrf2/ARE activator 2 Activator / 否
HY-170947 Antitumor agent-195 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nqo1 NCBI NCBI:1728
Mus musculus Nqo1 NCBI NCBI:18104
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