2. NF-κB Immunology/Inflammation Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS) DNA/RNA Synthesis PARP Quinone Reductase
  4. Ola-NC-SS-PEG-Lap

Ola-NC-SS-PEG-Lap 是一种选择性的免疫原性细胞死亡诱导剂。Ola-NC-SS-PEG-Lap 利用 NQO1 生物活化化合物与 PARP 抑制剂之间的协同作用，选择性地诱导肿瘤细胞发生免疫原性细胞死亡，而不损伤正常细胞。Ola-NC-SS-PEG-Lap 可诱导活性氧 (ROS) 的积累、增加 DNA 损伤。Ola-NC-SS-PEG-Lap 可被谷胱甘肽 (GSH) 激活并释放 Ola，最终与 Lap 部分产生协同抗肿瘤作用。Ola-NC-SS-PEG-Lap 对结肠癌具有抗癌活性。

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Ola-NC-SS-PEG-Lap

Ola-NC-SS-PEG-Lap Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

Ola-NC-SS-PEG-Lap 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ola-NC-SS-PEG-Lap is a selective immunogenic cell death inducer. Ola-NC-SS-PEG-Lap exploits the synergistic interplay between an NQO1-bioactivated compound and a PARP inhibitor to selectively induce immunogenic cell death in tumor cells without harming normal cells. Ola-NC-SS-PEG-Lap induces ROS accumulation, increases DNA damage. Ola-NC-SS-PEG-Lap can be activated by GSH and release Ola, ultimately producing the synergistic antitumor effect with the Lap portion. Ola-NC-SS-PEG-Lap has anti-cancer activity against colon cancer[1].

IC50 & Target[1]

NQO1

 

分子量

1147.25

Formula

C55H63FN6O16S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ola-NC-SS-PEG-Lap 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ola-NC-SS-PEG-LapReactive Oxygen Species (ROS)DNA/RNA SynthesisPARPQuinone Reductasepoly ADP ribose polymerase anti-cancerMC38Inhibitorinhibitorinhibit

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