Drd2 - dopamine receptor D2 Gene

中文名称：多巴胺受体 D2

种属: Rattus norvegicus

关于 Drd2

功能概要

该基因编码的蛋白可启动多种功能，包括多巴胺结合活动；多巴胺神经递质受体活性，通过 Gi/Go 耦合；和离子型谷氨酸受体结合活性。涉及多个过程，包括化学突触传递的调节；神经系统发育；蛋白质修饰过程的调控。位于几种细胞成分中，包括细胞质囊泡；侧质膜；和周核体。在 GABA 能突触和谷氨酸能突触中活跃。是突触后膜的组成部分和突触前膜的组成部分。用于研究帕金森症；可卡因依赖；和卵巢过度刺激综合征。多种疾病的生物标志物，包括图雷特综合征；药物精神病;高催乳素血症;阿片类药物依赖（多种）；和中毒性脑病。该基因的人类直系同源物与多种疾病有关，包括终末期肾病；精神抑郁症；有先兆的偏头痛；肥胖;和 2 型糖尿病。与人类 DRD2（多巴胺受体 D2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and ionotropic glutamate receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of protein modification process. Located in several cellular components, including cytoplasmic vesicle; lateral plasma membrane; and perikaryon. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study Parkinsonism; cocaine dependence; and ovarian hyperstimulation syndrome. Biomarker of several diseases, including Gilles de la Tourette syndrome; drug psychosis; hyperprolactinemia; opiate dependence (multiple); and toxic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (Dopamine Receptor D2). [provided by Alliance of Genome Resources, Apr 2022]