BAZ2B - bromodomain adjacent to zinc finger domain 2B Gene

中文名称：与锌指结构域 2B 相邻的溴结构域

种属: Homo sapiens

同用名: WALp4

基因 ID: 29994 | 基因类型: protein coding

关于 BAZ2B

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:159,315,312-159,712,442 (from NCBI)

This gene has 17 transcripts (splice variants), 313 orthologues and 11 paralogues. Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 5.2) and 25 other tissues.

功能概要

该基因属于溴域基因家族。该基因家族的成员编码的蛋白质是染色质重塑复合物的组成部分。编码的蛋白质在组蛋白肽筛选中显示出对激活 H3K14Ac 标记的强烈偏好，表明在转录激活中的潜在作用。该基因可能与心源性猝死 (SCD) 的易感性有关。[RefSeq 提供，2016 年 8 月]

This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac MARK in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). [provided by RefSeq, Aug 2016]

BAZ2B 基因产物(4)

mRNA	Protein	Name
NM_001289975.1	NP_001276904.1	bromodomain adjacent to zinc finger domain protein 2B isoform b
NM_001329857.2	NP_001316786.1	bromodomain adjacent to zinc finger domain protein 2B isoform c
NM_001329858.2	NP_001316787.1	bromodomain adjacent to zinc finger domain protein 2B isoform d
NM_013450.4	NP_038478.2	bromodomain adjacent to zinc finger domain protein 2B isoform a

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10662543	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	25593309	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BAZ2B 蛋白结构

MBD

DDT

PHD

Bromodomain

0
400
800
1200
1600
2000
2168 a.a.

蛋白主名

其他名称

bromodomain adjacent to zinc finger domain protein 2B

BAZ2B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BAZ2B	Q9UIF8	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	CTBP2	Homo sapiens	P56545-3	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	CTBP2	Homo sapiens	P56545-3	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	SEPTIN2	Homo sapiens	Q15019-3	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	SEPTIN2	Homo sapiens	Q15019-3	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	SEPTIN2	Homo sapiens	Q15019-3	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	RASGEF1B	Homo sapiens	Q0VAM2-3	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	RASGEF1B	Homo sapiens	Q0VAM2-3	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	RASGEF1B	Homo sapiens	Q0VAM2-3	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	BIVM	Homo sapiens	Q86UB2	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	BIVM	Homo sapiens	Q86UB2	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	BIVM	Homo sapiens	Q86UB2	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	APIP	Homo sapiens	Q96GX9	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	APIP	Homo sapiens	Q96GX9	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	APIP	Homo sapiens	Q96GX9	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	HSF2BP	Homo sapiens	O75031	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
种属内	BAZ2B	Q9UIF8	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	FXR2	Homo sapiens	P51116	Y2H Array	32296183
种属内	BAZ2B	Q9UIF8	FXR2	Homo sapiens	P51116	Validated Y2H	32296183
种属内	BAZ2B	Q9UIF8	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Splenic Flexure Cancer

Ca Splenic Flexure - Colon	Malignant Neoplasm Of Splenic Flexure
Malignant Tumor Of Splenic Flexure	Malignant Neoplasm Of Splenic Flexure Of Colon

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15658	GSK2801		99.69%	否
HY-19336	BAZ2-ICR	Inhibitor	99.95%	否
HY-107477	GSK8573		99.53%	否
HY-168448	dBAZ2	Degrader	/	否
HY-168453	dBAZ2B	Degrader	/	否
HY-RS01380	BAZ2B Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17378	Baz2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23832	Baz2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	BAZ2B	MGD	MGI:2442782
Bos taurus	BAZ2B	VGNC	VGNC:55328
Rattus norvegicus	BAZ2B	RGD	RGD:1309801
Canis familiaris	BAZ2B	VGNC	VGNC:53090

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

BAZ2B - bromodomain adjacent to zinc finger domain 2B Gene

关于 BAZ2B

功能概要

BAZ2B 基因产物(4)

BAZ2B 蛋白结构

BAZ2B 蛋白互作信息

关联疾病

直系同源

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BAZ2B - bromodomain adjacent to zinc finger domain 2B Gene

关于 BAZ2B

功能概要

BAZ2B 基因产物(4)

BAZ2B 蛋白结构

BAZ2B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z