KCNJ15 - potassium inwardly rectifying channel subfamily J member 15 Gene

中文名称：钾内向整流通道亚家族 J 成员 15

种属: Homo sapiens

同用名: IRKK; KIR1.3; KIR4.2

基因 ID: 3772 | 基因类型: protein coding

关于 KCNJ15

Cytogenetic location: 21q22.13-q22.2 Genomic coordinates (GRCh38): 21:38,229,926-38,307,357 (from NCBI)

This gene has 22 transcripts (splice variants), 198 orthologues and 15 paralogues. Biased expression in kidney (RPKM 38.5), thyroid (RPKM 23.6) and 6 other tissues.

功能概要

钾通道存在于大多数哺乳动物细胞中，它们参与广泛的生理反应。该基因编码的蛋白是一种完整的膜蛋白和内向整流型钾通道。编码的蛋白质更倾向于让钾流入细胞而不是流出细胞。已发现该基因有八种编码相同蛋白质的转录变体。[RefSeq 提供，2013 年 2 月]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type Potassium Channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]

KCNJ15 基因产物(8)

mRNA	Protein	Name
NM_001276435.2	NP_001263364.1	ATP-sensitive inward rectifier potassium channel 15
NM_001276436.2	NP_001263365.1	ATP-sensitive inward rectifier potassium channel 15
NM_001276437.2	NP_001263366.1	ATP-sensitive inward rectifier potassium channel 15
NM_001276438.2	NP_001263367.1	ATP-sensitive inward rectifier potassium channel 15
NM_001276439.2	NP_001263368.1	ATP-sensitive inward rectifier potassium channel 15
NM_002243.5	NP_002234.2	ATP-sensitive inward rectifier potassium channel 15
NM_170736.3	NP_733932.1	ATP-sensitive inward rectifier potassium channel 15
NM_170737.3	NP_733933.1	ATP-sensitive inward rectifier potassium channel 15

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9647694	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCNJ15 蛋白结构

IRK

0
100
200
300
375 a.a.

蛋白主名

其他名称

ATP-sensitive inward rectifier potassium channel 15

inward rectifier K(+) channel Kir1.3

KCNJ15 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	KCNJ15	Q99712	Patj	Mus musculus	Q63ZW7	Y2H	9647694

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Vitreoretinal Degeneration, Snowflake Type

Snowflake Vitreoretinal Degeneration	SVD
Snowflake Degeneration In Hereditary Vitreoretinal Degeneration

Hypomagnesemia 4, Renal

Renal Hypomagnesemia 4	HOMG4
Hypomagnesemia, Renal, Normocalciuric	Hypomagnesemia 4
Renal Hypomagnesemia Normocalciuric	Hypomagnesemia, Type 4, Renal

Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance

Sesame Syndrome	East Syndrome
SESAMES	Epilepsy, Ataxia, Sensorineural Deafness And Tubulopathy
Seizures, Sensorineural Deafness, Ataxia, Mental Retardation And Electrolyte Imbalance	Epilepsy-Ataxia-Sensorineural Deafness-Tubulopathy Syndrome
Seizures-Sensorineural Deafness-Ataxia-Intellectual Disability-Electrolyte Imbalance Syndrome	Epilepsy, Ataxia, Sensorineural Deafness, And Tubulopathy
Seizures - Sensorineural Deafness - Ataxia - Intellectual Disability - Electrolyte Imbalance	Epilepsy-Ataxia-Sensorineural Hearing Loss-Tubulopathy Syndrome
Seizures-Sensorineural Hearing Loss-Ataxia-Intellectual Disability-Electrolyte Imbalance Syndrome	Seizures, Sensorineural Deafness, Ataxia, Intellectual Disability, And Electrolyte Imbalance
Epilepsy Ataxia Sensorineural Deafness And Tubulopathy	Seizures, Sensorineural Deafness, Ataxia, Intellectual Disability, And Electrolyte Imbalance Syndrome

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07142	KCNJ15 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	KCNJ15	VGNC	VGNC:67913
Macaca mulatta	KCNJ15	VGNC	VGNC:73986
Mus musculus	KCNJ15	MGD	MGI:1310000
Bos taurus	KCNJ15	VGNC	VGNC:30458
Rattus norvegicus	KCNJ15	RGD	RGD:621662
Canis familiaris	KCNJ15	VGNC	VGNC:42261

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