2. Gene
  3. Rc3h1 - RING CCCH (C3H) domains 1 Gene

Rc3h1 - RING CCCH (C3H) domains 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Gm551; mKIAA2025; 5730557L09Rik

基因 ID: 381305 | 基因类型: protein coding

关于 Rc3h1

功能概要

Enables RNA binding activity and zinc ion binding activity. Involved in several processes, including P-body assembly; negative regulation of lymphocyte activation; and regulation of RNA metabolic process. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; lymphocyte homeostasis; and positive regulation of NIK/NF-kappaB signaling. Located in P-body and cytoplasmic stress granule. Used to study peripheral T-cell lymphoma and systemic lupus erythematosus. Orthologous to human RC3H1 (ring finger and CCCH-type domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Rc3h1 基因产物(1)

mRNA Protein Name
NM_001024952.2 NP_001020123.1 roquin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA stem-loop binding IDA
IDA: 通过直接分析推断
25026077 MGI
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
20639877 MGI
enables mRNA binding IDA
IDA: 通过直接分析推断
23583643 MGI
enables miRNA binding IDA
IDA: 通过直接分析推断
25697406 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
20639877 MGI
enables zinc ion binding IDA
IDA: 通过直接分析推断
25697406 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-UTR-mediated mRNA destabilization IDA
IDA: 通过直接分析推断
26000482 MGI
acts upstream of or within B cell homeostasis IGI
IGI: 通过遗传相互作用推断
23583643 MGI
involved in P-body assembly IMP
IMP: 通过突变表型推断
20639877 MGI
acts upstream of or within T cell homeostasis IGI
IGI: 通过遗传相互作用推断
23583643 MGI
acts upstream of or within T cell proliferation IGI
IGI: 通过遗传相互作用推断
23583643 MGI
involved in T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
25282160 MGI
acts upstream of or within T follicular helper cell differentiation IGI
IGI: 通过遗传相互作用推断
23583643 MGI
acts upstream of or within lymph node development IGI
IGI: 通过遗传相互作用推断
23583643 MGI
involved in negative regulation of B cell proliferation IMP
IMP: 通过突变表型推断
18172933 MGI
involved in negative regulation of T-helper 17 cell differentiation IMP
IMP: 通过突变表型推断
25282160 MGI
acts upstream of or within negative regulation of T-helper cell differentiation IMP
IMP: 通过突变表型推断
15917799 MGI
involved in negative regulation of activated T cell proliferation IMP
IMP: 通过突变表型推断
18172933 MGI
involved in negative regulation of germinal center formation IMP
IMP: 通过突变表型推断
18172933 MGI
involved in nuclear-transcribed mRNA catabolic process IMP
IMP: 通过突变表型推断
20639877 MGI
involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
IMP: 通过突变表型推断
26000482 MGI
involved in positive regulation of mRNA catabolic process IDA
IDA: 通过直接分析推断
26000482 MGI
involved in positive regulation of mRNA catabolic process IMP
IMP: 通过突变表型推断
25026077 MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
23583643 MGI
acts upstream of or within post-transcriptional regulation of gene expression IDA
IDA: 通过直接分析推断
23583643 MGI
involved in post-transcriptional regulation of gene expression IMP
IMP: 通过突变表型推断
20639877 MGI
involved in regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
15917799 MGI
acts upstream of or within regulation of gene expression IDA
IDA: 通过直接分析推断
23583643 MGI
involved in regulation of germinal center formation IMP
IMP: 通过突变表型推断
15917799 MGI
involved in regulation of mRNA stability IMP
IMP: 通过突变表型推断
18172933 MGI
involved in regulation of miRNA metabolic process IMP
IMP: 通过突变表型推断
25697406 MGI
acts upstream of or within spleen development IGI
IGI: 通过遗传相互作用推断
23583643 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
20639877 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
15917799 MGI
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
15917799 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

roquin-1

RING finger and C3H zinc finger protein 1

RING finger and CCCH-type zinc finger domain-containing protein 1

probable E3 ubiquitin-protein ligase Roquin

protein Sanroque

roquin

Rc3h1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Rc3h1 Q4VGL6 Edc4 Mus musculus Q3UJB9
Anti Bait CoIP
20639877
种属内
Rc3h1 Q4VGL6 Ago2 Mus musculus Q8CJG0
Anti Bait CoIP
25697406
种属内
Rc3h1 Q4VGL6 Ago2 Mus musculus Q8CJG0
Anti Tag CoIP
25697406
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11777 RC3H1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rc3h1 NCBI NCBI:149041
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