2. Gene
  3. SOX1 - SRY-box transcription factor 1 Gene

SOX1 - SRY-box transcription factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SRY-box 转录因子 1

种属: Homo sapiens

基因 ID: 6656 | 基因类型: protein coding

关于 SOX1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:112,067,149-112,071,706 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and 20 paralogues.

功能概要

这种无内含子的基因编码参与胚胎发育调节和细胞命运决定的转录因子 SOX (SRY 相关 HMG 盒) 家族的成员。编码的蛋白质在与其他蛋白质形成蛋白质复合物后可以充当转录激活剂。在小鼠中，一种类似的蛋白质调节着γ-晶状体蛋白基因，对晶状体发育至关重要。[RefSeq 提供，2008 年 7 月]

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with Other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008]

SOX1 基因产物(1)

mRNA Protein Name
NM_005986.3 NP_005977.2 transcription factor SOX-1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20049565 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20929579 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SOX1 蛋白结构

HMG_box

HMG_box: HMG (high mobility group) box (51 - 119)

SOXp

SOXp: SOX transcription factor (120 - 224)

  • 0
  • 100
  • 200
  • 300
  • 391 a.a.
蛋白主名 其他名称

transcription factor SOX-1

SRY (sex determining region Y)-box 1

SOX1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SOX1 O00570 STAT3 Homo sapiens P40763
Anti Bait CoIP
20929579
种属间: 跨种属相互作用 种属内: 同种属相互作用

SOX1 抗体

目录号 产品名 应用 反应物种
HY-P80330 SOX1 Antibody (YA070) WB, ICC/IF, IHC-P Human, Mouse, Rat
HY-P87081 SOX1 Antibody (YA6774) WB, IHC-F, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Lambert-Eaton Myasthenic Syndrome

Lambert-Eaton Syndrome

Eaton-Lambert Syndrome

Lems

Lambert Eaton Myasthenic Syndrome

Eaton Lambert Syndrome

Lambert Eaton Syndrome

Myasthenic Syndrome Of Lambert-Eaton

Myasthenic-Myopathic Syndrome Of Lambert-Eaton

Lems - [Lambert-Eaton Myasthenic Syndrome]
Bilateral Hypoactive Labyrinth

Hypoactive Bilateral Labyrinthine Dysfunction

Hypoactive Labyrinth, Bilateral
Inner Ear Disease

Labyrinthine Dysfunction

Diseases Of Inner Ear

Labyrinthine Disease

Abnormality Of The Inner Ear

Labyrinth Diseases

Labyrinthine Disorder

Nonfunctioning Labyrinth

Labyrinthine Loss Of Function

Labyrinthine Syndrome

Labyrinthine Disorder Nos
Paraneoplastic Polyneuropathy
Neuromuscular Junction Disease

Neuromuscular Junction Diseases
Autoimmune Disease Of Peripheral Nervous System
Limbic Encephalitis
Autoimmune Epilepsy
Retinitis Pigmentosa 50

RP50

Retinitis Pigmentosa, Concentric

Retinitis Pigmentosa-50

Retinitis Pigmentosa Concentric
Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm
Postinfectious Encephalitis

Postinfective Encephalitis

Secondary Encephalitis
Cataract 34, Multiple Types

Cataract, Autosomal Recessive Congenital 3

Cataract 34 Multiple Types

CTRCT34

Catc3

Cataract 34, Multiple Types, With Or Without Microcornea

Autosomal Recessive Congenital Cataract 3

Cataract 34 Multiple Types With Or Without Microcornea

Cataract, Multiple Types, Type 34
Germ Cell Cancer

Malignant Germ Cell Tumor

Neoplasms, Germ Cell And Embryonal

Germ Cell Neoplasm

Germ Cell Tumour

Malignant Tumor Of The Germ Cell

Neoplasms Germ Cell

Malignant Germ Cell Neoplasm
Neuromuscular Disease

Neuromuscular Diseases

Neuromuscular Disorders

Neuromuscular Disorder
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-133028 CKI-7 free base Inhibitor 99.31% 否
HY-W011109 CKI-7 Inhibitor 99.97% 否
HY-RS13582 SOX1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19383 Sox1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25875 Sox1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SOX1 RGD RGD:6487636
Bos taurus SOX1 VGNC VGNC:35140
Mus musculus SOX1 MGD MGI:98357
Canis familiaris SOX1 VGNC VGNC:57497
Others SOX1 NCBI
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