GPR50 - G protein-coupled receptor 50 Gene

中文名称：G 蛋白偶联受体 50

种属: Homo sapiens

同用名: H9; Mel1c

基因 ID: 9248 | 基因类型: protein coding

关于 GPR50

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,176,584-151,182,856 (from NCBI)

This gene has 1 transcript (splice variant), 181 orthologues and 33 paralogues. Low expression observed in reference dataset.

功能概要

该基因产物属于 G 蛋白偶联受体 1 家族。尽管这种蛋白质与褪黑激素受体具有相似性，但它不结合褪黑激素，但它通过异二聚化抑制褪黑激素受体 1A 的功能。该基因的多态性变异与女性双相情感障碍有关。[RefSeq 提供，2010 年 1 月]

This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits Melatonin Receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]

GPR50 基因产物(1)

mRNA	Protein	Name
NM_004224.3	NP_004215.2	melatonin-related receptor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16778767	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPR50 蛋白结构

7tm_1

0
100
200
300
400
500
617 a.a.

蛋白主名

其他名称

melatonin-related receptor

GPR50 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GPR50	Q13585	ZNF572	Homo sapiens	Q7Z3I7	Y2H Prey Pooling	25416956
种属内	GPR50	Q13585	MT1A	Homo sapiens	P04731	IF	16778767
种属内	GPR50	Q13585	MT1A	Homo sapiens	P04731	BRET	16778767
种属内	GPR50	Q13585	MT1A	Homo sapiens	P04731	Anti Tag CoIP	16778767

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome

Mrxs13	Lindsay-Burn Syndrome
Ppm-X	Ppm-X Syndrome
Mental Retardation With Psychosis, Pyramidal Signs, And Macroorchidism	Mental Retardation, X-Linked, Syndromic 13
X-Linked Mental Retardation 79	X-Linked Mental Retardation With Spasticity
Intellectual Deficit, X-Linked - Psychosis - Macroorchidism	Intellectual Disability Psychosis Macroorchidism
Intellectual Disability With Psychosis, Pyramidal Signs, And Macroorchidism	Intellectual Disability, X-Linked, Syndromic 13
Ppmx	X-Linked Mental Retardation, Syndromic 13

Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome	Delayed Sleep Phase Syndrome, Susceptibility To
DSPD	Delayed Sleep Phase Disorder, Susceptibility To
DSPS	Sleep Phase, Delayed, Disorder
Sleep Phase Syndrome, Delayed, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Scoliosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05717	GPR50 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20942	Gpr50 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS27459	Gpr50 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GPR50	MGD	MGI:1333877
Macaca mulatta	GPR50	VGNC	VGNC:73138
Canis familiaris	GPR50	VGNC	VGNC:41437
Rattus norvegicus	GPR50	RGD	RGD:619863
Bos taurus	GPR50	VGNC	VGNC:29589

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