2. PROTAC
  3. Molecular Glues
  4. GSPT2 degrader-1

GSPT2 degrader-1 (compound 619) 是一种靶向 GSPT2 的选择性分子胶 (molecular glue) 降解剂。GSPT2 degrader-1 包含 Thalidomide (HY-14658) 和 MDEG-541 (HY-150259) 的连接子。GSPT2 degrader-1 可诱导 GSPT2 降解，但不降解 GSPT1 或骨髓细胞瘤癌基因 (MYC)。GSPT2 degrader-1 可用于胃肠道肿瘤的研究。

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GSPT2 degrader-1

GSPT2 degrader-1 Chemical Structure

CAS No. : 3093413-09-0

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生物活性

GSPT2 degrader-1 (compound 619) is a selective molecular glue GSPT2 degrader targeting GSPT2. GSPT2 degrader-1 contains Thalidomide (HY-14658) and the linker of MDEG-541 (HY-150259). GSPT2 degrader-1 induces the degradation, but not GSPT1 or myelocytomatosis oncogene (MYC). GSPT2 degrader-1 can be used for research of gastrointestinal cancer[1].

分子量

532.59

Formula

C29H32N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSPT2 degrader-1 相关分类

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Keywords:

GSPT2 degrader-13093413-09-0Molecular Gluesmolecular glueGSPT2gastrointestinalInhibitorinhibitorinhibit

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