2. Cytoskeleton
  3. Integrin
  4. GW559090

GW559090 是一种选择性、竞争性且高亲和力的 α4 整合素拮抗剂，其对 α4β1 的 Kd 值为 0.19 nM。GW559090 能有效阻断 α4β1 与血管细胞黏附分子 1 (VCAM-1) 和纤连蛋白的结合，其 IC50 值分别为 7.72 和 8.04 nM。GW559090 还能抑制 α4β7 与黏膜地址素细胞黏附分子 1 (MAdCAM-1) 之间的相互作用 (IC50 值为 23 nM)。GW559090 可抑制眼部的炎性浸润，修复角膜屏障并恢复杯状细胞的功能。GW559090 可用于干燥综合征相关干眼症的研究。

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GW559090

GW559090 Chemical Structure

CAS No. : 278598-52-0

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GW559090 相关抗体

Top Publications Citing Use of Products

查看 Integrin 亚型特异性产品:

查看所有亚型
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd of 0.19 nM for α4β1. GW559090 can effectively block the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin with IC50 values of 7.72 and 8.04 nM. GW559090 also inhibits the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (IC50 = 23 nM). GW559090 can inhibit inflammatory infiltration in the eyes, repair the corneal barrier and restore the function of goblet cells. GW559090 can be used for research of Sjögren's syndrome associated dry eye[1].

IC50 & Target[1]

α4β1

0.19 nM (Kd)

分子量

596.67

Formula

C31H40N4O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GW559090 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW559090278598-52-0GW 559090GW-559090IntegrinInhibitorinhibitorinhibit

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