2. Apoptosis PI3K/Akt/mTOR
  3. Apoptosis Akt mTOR
  4. HBF-0079

HBF-0079 是一种选择性的抗肝细胞癌剂。HBF-0079 可诱导细胞周期停滞和凋亡 (Apoptosis)。HBF-0079 通过 AKT 和 mTOR 调节细胞生长和抗凋亡信号传导。HBF-0079 表现出对肝细胞癌的抗肿瘤活性。

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HBF-0079

HBF-0079 Chemical Structure

CAS No. : 315702-93-3

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HBF-0079 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HBF-0079 is a selective anti-hepatocellular carcinoma agent. HBF-0079 induces cell cycle arrest and Apoptosis. HBF-0079 modulates cell-growth and anti-apoptotic signaling through AKT and mTOR. HBF-0079 exhibits antitumor activity against hepatocellular carcinoma[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
> 30 μM
Compound: 10
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay
[PMID: 18774291]
Huh-7 CC50
1.1 μM
Compound: HBF-0079
Cytotoxicity against human HuH7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HuH7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
[PMID: 27793566]
分子量

255.30

Formula

C12H9N5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HBF-0079 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBF-0079315702-93-3HBF0079HBF 0079ApoptosisAktmTORPKBProtein kinase BMammalian target of RapamycinHuh7Hep3BHepaRGHepG2Hepatocellular carcinomanude miceInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-18203
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