2. MAPK/ERK Pathway Immunology/Inflammation
  3. MAP4K Interleukin Related
  4. HPK1-IN-64

HPK1-IN-64 是一种强效，选择性且具有口服活性的 HPK1 抑制剂，其 IC50 值为 1.9 nM 。HPK1-IN-64 对 GLK、MAP4K5、TBK1、TNIK 等脱靶激酶的选择性分别超过 100 倍、80 倍、300 倍、350 倍。HPK1-IN-64 能抑制 SLP76 蛋白的磷酸化和 IL-2 的分泌。HPK1-IN-64 可用于癌症的研究，如结直肠癌。

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HPK1-IN-64

HPK1-IN-64 Chemical Structure

CAS No. : 3034320-17-4

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HPK1-IN-64 相关抗体

Top Publications Citing Use of Products

查看 MAP4K 亚型特异性产品:

查看所有亚型
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HPK1-IN-64 is a potent, selective, and orally active HPK1 inhibitor with an IC50 value of 1.9 nM. HPK1-IN-64 exhibits selectivity exceeding 100-fold, 80-fold, 300-fold, and 350-fold against off-target kinases such as GLK, MAP4K5, TBK1, and TNIK, respectively. HPK1-IN-64 inhibits SLP76 protein phosphorylation and IL-2 secretion. HPK1-IN-64 may be used in cancer research, such as for colorectal cancer[1].
IC50 & Target[1]

HPK1

1.9 nM (IC50)

IL-2

 

体内研究
(In Vivo)

HPK1-IN-64 (Compound 6) (1.5-5 mg/kg；口服；一天两次) 抑制 CT26 荷瘤小鼠中的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: (CT26 tumor model)[1]
Dosage: 1.5 mg/kg, 5 mg/kg
Administration: p.o.; twice daily
Result: Inhibited tumor growth with TGI of 56% and 93%.
分子量

499.60

Formula

C29H33N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HPK1-IN-64 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-643034320-17-4MAP4KInterleukin RelatedMAPK Kinase Kinase KinaseILpotent inhibitor,AI,cancer immunotherapy,molecule generation,SE(3)-equivariant,HPK1,drug discovery,CT26,TGIInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-179111
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