2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. HS-36

HS-36 是一种高选择性的、口服有效的 CDK4 和 CDK9 双重抑制剂，其 IC50 分别为 18.9 和 4.2 nM。HS-36 对多种癌细胞具有纳摩尔级别的强效活性，诱导 G0/G1 期阻滞和促进细胞凋亡 (apoptosis)。HS-36 在 MV-4-11 肿瘤的小鼠模型中高效抑制肿瘤生长。HS-36 可用于研究急性髓系白血病。

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HS-36

HS-36 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

HS-36 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HS-36 is a highly selective and orally active dual inhibitor of CDK4 and CDK9 with IC50 values of 18.9 and 4.2 nM respectively. HS-36 exhibits nanomolar-level potent activity against various cancer cells, inducing G0/G1 phase arrest and promoting cell apoptosis. HS-36 efficiently inhibits tumor growth in a mouse model of MV-4-11 tumors. HS-36 can be used for the study of acute myeloid leukemia[1].

IC50 & Target[1]

CDK9

4.2 nM (IC50)

CDK4

18.9 nM (IC50)

CDK2

197.3 nM (IC50)

CDK6

125.5 nM (IC50)

CDK9

216.9 nM (IC50)

CDK1

> 500 nM (IC50)

CDK7

> 500 nM (IC50)

CDK12

> 500 nM (IC50)

分子量

435.47

Formula

C24H25N3O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HS-36 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HS-36HS36HS 36CDKApoptosisCyclin dependent kinaseOxazolonylflavoneCDK4/9 dual inhibitorsAntitumor efficacyOral bioavailabilityDrug resistanceMolecular dockingPharmacokineticsInhibitorinhibitorinhibit

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产品名称：
HS-36
目录号：
HY-180912
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