2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis Bcl-2 Family Caspase
  4. iMPZ-8

iMPZ-8 是一种 β-微管蛋白 (β-tubulin) 聚合抑制剂，可抑制 β-tubulin 蛋白表达、破坏微管结构、损伤微管组织。iMPZ-8 可抑制癌细胞增殖，降低癌细胞的迁移和定植能力。iMPZ-8 可诱导细胞 G2/M 期阻滞，并通过 BAX-Caspase-3 内源性凋亡信号通路诱导凋亡 (apoptosis)。iMPZ-8 可用于癌症研究，例如乳腺癌、神经母细胞瘤和结肠癌。

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iMPZ-8

iMPZ-8 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

iMPZ-8 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

iMPZ-8 is a β-tubulin polymerization inhibitor that inhibits β-tubulin protein expression, disrupts microtubule structure, impairs microtubule organization. iMPZ-8 inhibits proliferation and reduces cellular migration and colonization in cancer cells. iMPZ-8 induces G2/M phase arrestand induces apoptosis via the BAX-Caspase-3 intrinsic apoptotic signaling pathway. iMPZ-8 can be used for the research of cancer, suah as breast cancer, neuroblastoma and colon cancer[1].

IC50 & Target[1]

Bax

 

Bcl-2

 

Caspase 3

 

体外研究
(In Vitro)

iMPZ-8 (1-80 μM；72 h) 可强效抑制 MDA-MB-231、SH-SY5Y 和 DLD-1 三种癌细胞的增殖，其对应的 IC50 值分别为 7.5 μM、9.2 μM 和 19.7 μM[1]。
iMPZ-8 (3 μM；48 h) 可显著抑制 MDA-MB-231 细胞中 β-tubulin的表达，并破坏微管结构[1]。
iMPZ-8 (3 μM；48 h) 可使 MDA-MB-231 细胞的迁移能力抑制约 50%[1]。
iMPZ-8 (3 μM；7 至 10 天) 可使 MDA-MB-231 细胞的集落形成能力降低约 30%[1]。
iMPZ-8 (3 μM；48 h) 可诱导 MDA-MB-231 细胞发生 G2/M 期细胞周期阻滞[1]。
iMPZ-8 (3 μM；48 h) 通过 BAX-Caspase-3 通路诱导 MDA-MB-231 细胞发生内源性凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

iMPZ-8 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, SH-SY5Y, DLD-1
Concentration: 1-80 μM
Incubation Time: 72 h
Result: Exhibited antiproliferative activity with IC50 values of 7.5 μM in MDA-MB-231 cells, 9.2 μM in SH-SY5Y cells, and 19.7 μM in DLD-1 cells.

ELISA Assay[1]

Cell Line: MDA-MB-231
Concentration: 3 μM
Incubation Time: 48 h
Result: Markedly inhibited β-tubulin protein expression, with effects comparable to Nocodazole (HY-13520) (a known β-tubulin antagonist).

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 μM
Incubation Time: 48 h
Result: Induced accumulation of cells in the G2/M phase of the cell cycle, similar to Nocodazole.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 μM
Incubation Time: 48 h
Result: Induced accumulation in early and late apoptosis.
Increased BAX and Caspase 3 levels and reduced Bcl-2 levels.
分子量

382.41

Formula

C23H18N4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

iMPZ-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iMPZ-8iMPZ8iMPZ 8Microtubule/TubulinApoptosisBcl-2 FamilyCaspaseMDA-MB-231neuroblastomaβ-tubulinmicrotubule structureSH-SY5YG2/M phasebreast cancerBAX-Caspase-3microtubule organizationInhibitorinhibitorinhibit

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目录号：
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