2. GPCR/G Protein MAPK/ERK Pathway Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Ras CDK Mitochondrial Metabolism
  4. KRAS G13D-IN-2

KRAS G13D-IN-2 (compound 8b) 是一种强效的口服活性 KRAS G13D 抑制剂，其 IC50 值分别为 1.95 μM (HCT-116G13D) 和 2.16 μM (HCT-15G13D)。KRAS G13D-IN-2 可诱导 G1 期阻滞和线粒体膜 (mitochondrial membrane) 去极化。KRAS G13D-IN-2 通过抑制 CDK6/TWIST1 诱导细胞衰老。KRAS G13D-IN-2 可抑制小鼠模型中的肿瘤生长。KRAS G13D-IN-2 可用于 KRASG13D 突变型结直肠癌的研究。

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KRAS G13D-IN-2

KRAS G13D-IN-2 Chemical Structure

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KRAS G13D-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

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K-Ras H-Ras N-Ras Ras

查看 CDK 亚型特异性产品:

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRAS G13D-IN-2 (compound 8B) is a potent orally active KRAS G13D inhibitor with IC50 values of 1.95 μM (HCT-116G13D) and 2.16 μM (HCT-15G13D). KRAS G13D-IN-2 induces G1-phase arrest and mitochondrial membrane depolarization. KRAS G13D-IN-2 induces senescence through CDK6/TWIST1 inhibition. KRAS G13D-IN-2 inhibits tumor growth in murine models. KRAS G13D-IN-2 can be used for KRASG13D-mutant colorectal cancer research[1].

IC50 & Target[1]

CDK6

703 nM ()

KRAS G13D

 

分子量

584.87

Formula

C36H60N2O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS G13D-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G13D-IN-2RasCDKMitochondrial MetabolismCyclin dependent kinaseKRAS G13DHCT-15G13DHCT-116G13DCDK6senescenceTWIST1KRASG13D-mutant colorectal cancerInhibitorinhibitorinhibit

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