2. PROTAC Metabolic Enzyme/Protease
  3. Molecular Glues Phosphoglycerate Dehydrogenase (PHGDH)
  4. LXH-3-71

LXH-3-71 是一种强效的分子胶 (molecular glue) PHGDH 降解剂。LXH-3-71 可与 PHGDH 和 DDB1-CRL E3 连接酶形成动态嵌合体。LXH-3-71 在体外和体内均能调节结直肠癌细胞 (CRC) 的干性。LXH-3-71 可用于结直肠癌研究。

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LXH-3-71

LXH-3-71 Chemical Structure

CAS No. : 2251753-65-6

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规格 价格 是否有货 数量
5 mg ￥1700
1 - 2 周
10 mg ￥2720
1 - 2 周
25 mg ￥5423
1 - 2 周
50 mg 询价 1 - 2 周
100 mg 询价 1 - 2 周
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

LXH-3-71 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LXH-3-71 is a potent molecular glue PHGDH degrader. LXH-3-71 forms a dynamic chimera between PHGDH and the DDB1-CRL E3 ligase. LXH-3-71 modulates the stemness of colorectal cancer cells (CRCs) both in vitro and in vivo. LXH-3-71 can be used for colorectal cancer research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
5.862 μM
Compound: 55
Cytotoxicity activity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse 4T1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
A-375 IC50
4.633 μM
Compound: 55
Cytotoxicity activity against human A375 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human A375 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
A549 IC50
12.35 μM
Compound: 55
Cytotoxicity activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
B16-F10 IC50
5.605 μM
Compound: 55
Cytotoxicity activity against mouse B16F10 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against mouse B16F10 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
MDA-MB-231 IC50
8.578 μM
Compound: 55
Cytotoxicity activity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
PANC-1 IC50
5.07 μM
Compound: 55
Cytotoxicity activity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
Cytotoxicity activity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay
[PMID: 30433783]
分子量

657.92

Formula

C41H59N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LXH-3-71 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LXH-3-712251753-65-6Molecular GluesPhosphoglycerate Dehydrogenase (PHGDH)PHGDHCSCsDDB1-CRL E3 ligasecolorectal cancerInhibitorinhibitorinhibit

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目录号：
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