2. GPCR/G Protein Neuronal Signaling JAK/STAT Signaling Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Apoptosis
  3. mGluR EGFR p38 MAPK Apoptosis
  4. LY456236

LY456236 是一种选择性、非竞争性和具有口服活性的谷氨酸受体 1 (mGlu1) 拮抗剂，可抑制磷酸肌醇水解，其 IC50 为 0.145 μM。LY456236 还能抑制 EGFR，IC50 为 0.918 μM。LY456236 通过抑制 MAPK 通路阻断细胞增殖，逆转了 DHPG (HY-12598A) 的抗凋亡 (apoptosis) 效果。LY456236 可用于惊厥研究。

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LY456236

LY456236 Chemical Structure

CAS No. : 338736-46-2

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1310
In-stock
5 mg ￥1191
In-stock
10 mg ￥1644
In-stock
25 mg ￥2652
In-stock
50 mg ￥3732
In-stock
100 mg ￥4944
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of LY456236:

LY456236 相关抗体

Top Publications Citing Use of Products

查看 mGluR 亚型特异性产品:

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 (mGlu1), which can inhibit phosphatidylinositol hydrolysis with an IC50 of 0.145 μM. LY456236 can also inhibit EGFR, with an IC50 of 0.918 μM. LY456236 blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti-apoptotic effect of DHPG (HY-12598A). LY456236 can be used in epilepsy research[1][2][3].

IC50 & Target[1][2]

mGluR 1

 

EGFR

0.918 μM (IC50)

体外研究
(In Vitro)

LY456236 (2 μM; 30 min) 降低 DHPG (HY-12598A) 刺激的 OCCM-30 增殖[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LY456236 相关抗体:

Cell Proliferation Assay[2]

Cell Line: OCCM-30 cells
Concentration: 2 μM
Incubation Time: 30 min, followed by 72 h incubation with DHPG (HY-12598A)
Result: Reduced DHPG-stimulated OCCM-30 proliferation.
体内研究
(In Vivo)

LY456236 在小鼠 (3-100 mg/kg; i.p.; once) 和大鼠 (10-60 mg/kg; oral; once) 中显示抗惊厥作用。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DBA/2 mice and CD1 mice, seizure models[3]
Dosage: 3-100 mg/kg
Administration: IP, once
Result: Produced dose-related anticonvulsant effects in preventing audiogenic-induced (tonic-clonic) seizures in DBA/2 mice, threshold electroshock-induced seizures in CD1 mice, and 6 Hz electroshock-induced seizures in CD1 mice.
Animal Model: Amygdala-kindled Sprague-Dawley rats[3]
Dosage: 10, 30 and 60 mg/kg
Administration: Oral, once
Result: Produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity. Produced a dose-related increase in the stimulus intensity required to produce generalized seizures.
分子量

317.78

Formula

C16H16ClN3O2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 250 mg/mL (786.71 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1468 mL 15.7342 mL 31.4683 mL
5 mM 0.6294 mL 3.1468 mL 6.2937 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

LY456236 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1468 mL 15.7342 mL 31.4683 mL 78.6708 mL
5 mM 0.6294 mL 3.1468 mL 6.2937 mL 15.7342 mL
10 mM 0.3147 mL 1.5734 mL 3.1468 mL 7.8671 mL
15 mM 0.2098 mL 1.0489 mL 2.0979 mL 5.2447 mL
20 mM 0.1573 mL 0.7867 mL 1.5734 mL 3.9335 mL
25 mM 0.1259 mL 0.6294 mL 1.2587 mL 3.1468 mL
30 mM 0.1049 mL 0.5245 mL 1.0489 mL 2.6224 mL
40 mM 0.0787 mL 0.3934 mL 0.7867 mL 1.9668 mL
50 mM 0.0629 mL 0.3147 mL 0.6294 mL 1.5734 mL
60 mM 0.0524 mL 0.2622 mL 0.5245 mL 1.3112 mL
80 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.9834 mL
100 mM 0.0315 mL 0.1573 mL 0.3147 mL 0.7867 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY456236338736-46-2LY 456236LY-456236mGluREGFRp38 MAPKApoptosisMetabotropic glutamate receptorsEpidermal growth factor receptorErbB-1HER1anticonvulsantDHPGOCCM-30DBA/2CD1 miceseizureInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-103566
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