Chemical induction of ferroptosis through GPX4 inhibition: Rational design of triazole-benzoxazine hybrids for melanoma therapy

Affiliations

• 1 School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210046, China.
• 2 Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China.
• 3 School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
• 4 Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao Special Administrative Region of China.
• 5 School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, China; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471003, China. Electronic address: lucyfly881104@163.com.
• 6 Precision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China; State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: huibin.xu@shgh.cn.
• 7 Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China; College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, China. Electronic address: shuxiang.xu@shgh.cn.