2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Glutathione Peroxidase Ferroptosis Reactive Oxygen Species (ROS)
  4. GPX4-IN-21

GPX4-IN-21 (Compound 4d) 是一种选择性的谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂。GPX4-IN-21 可诱导铁死亡 (ferroptosis)，并下调铁死亡相关蛋白 SLC7A11、SLC11A2 和 GPX4 的水平。GPX4-IN-21 可诱导活性氧 (ROS) 和 MDA 的积累。GPX4-IN-21 表现出强效的抗增殖活性。GPX4-IN-21 可用于癌症研究，如黑色素瘤。

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GPX4-IN-21

GPX4-IN-21 Chemical Structure

CAS No. : 3014384-72-3

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GPX4-IN-21 相关抗体

Top Publications Citing Use of Products

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GPX1 GPX4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GPX4-IN-21 (Compound 4d) is a selective glutathione peroxidase 4 (GPX4) inhibitor. GPX4-IN-21 can induce ferroptosis and downregulate the ferroptosis-related proteins SLC7A11, SLC11A2 and GPX4 levels. GPX4-IN-21 can induce ROS and MDA accumulation GPX4-IN-21 exhibits potent anti-proliferative activity. GPX4-IN-21 can be used for the research of cancer, such as melanoma[1].

IC50 & Target[1]

GPX4

 

体外研究
(In Vitro)

GPX4-IN-21 对黑色素瘤表现出强效的抗增殖活性，在 A375 细胞中的 IC50 值为 9.42 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GPX4-IN-21 相关抗体:
分子量

445.86

Formula

C23H16ClN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GPX4-IN-21 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPX4-IN-213014384-72-3Glutathione PeroxidaseFerroptosisReactive Oxygen Species (ROS)Inhibitorinhibitorinhibit

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