2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage Anti-infection
  3. Endogenous Metabolite Sirtuin HBV
  4. Nicotinamide (GMP Like)

Nicotinamide (GMP Like)  (Synonyms: Niacinamide (GMP Like); Nicotinic acid amide (GMP Like))

目录号: HY-B0150GL
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Nicotinamide (GMP Like) (Niacinamide (GMP Like)) 是 GMP Like 级别的 Nicotinamide (HY-B0150)。GMP Like 级别的小分子可用做细胞疗法中的辅助试剂。Nicotinamide 是维生素 B3 或烟酸的一种形式。Nicotinamide 可抑制 SIRT2 的活性，其 IC50 值为 2 μM。Nicotinamide 也抑制 SIRT1。Nicotinamide 增加细胞内 NAD+、ATP、ROS 水平。Nicotinamide 抑制肿瘤生长并提高生存率。Nicotinamide Hydrochloride 还具有抗-HBV 活性。

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Nicotinamide (GMP Like)

Nicotinamide (GMP Like) Chemical Structure

CAS No. : 98-92-0

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Nicotinamide (GMP Like) 的其他形式现货产品:

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Other Forms of Nicotinamide (GMP Like):

Nicotinamide (GMP Like) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nicotinamide (GMP Like) (Niacinamide (GMP Like)) is Nicotinamide (HY-B0150) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity[1][2][3][4].

体外研究
(In Vitro)

Nicotinamide (GMP Like) (0-50 mM，24/48 小时) 以时间依赖性和剂量依赖性方式减少 A375 和 SK-MEL-28 细胞中的细胞数量[1]。
Nicotinamide (GMP Like) (10-50 mM, 24 h ) 使 A375 细胞在 G1 期积累，在 S 期减少，在亚 G1 期 (细胞凋亡)增加[1]。
Nicotinamide (GMP Like) (1-50 mM，6 小时) 增加 A375 和 SK-MEL-28 细胞中的 NAD+、ATP 和 ROS 水平[1]。
Nicotinamide (GMP Like) (0.01-20 mM，1 小时) 在体外抑制纯化的 SIRT2 酶活性，EC50 为 2 μM[1]。
Nicotinamide (GMP Like) (0-64 mM) 抑制 HBV 在 HepAD38 和 HepG2.2.15 细胞中的复制[3]。
Nicotinamide (GMP Like) (10 mM，第 13 天) 通过抑制 CK1 和 ROCK 促进胰腺细胞从人胚胎干细胞 (hESC) 分化[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nicotinamide (GMP Like) 相关抗体:

Cell Viability Assay[1]

Cell Line: A375, SK-MEL-28, mouse B16-F10 cell
Concentration: 0, 1, 20, 50 mM
Incubation Time: 24 h, 48 h
Result: Reduced cell number in a dose-dependent manner with a strong inhibitory effect at 20mM and an almost complete effect at 50 mM.

Cell Cycle Analysis[1]

Cell Line: A375, SK-MEL-28
Concentration: 10, 20, 50 mM
Incubation Time: 24 h
Result: Arrested A375 cells in G1 phase.
体内研究
(In Vivo)

Nicotinamide (GMP Like) (腹腔注射，1500 和 1800 mg/Kg，每周 5 天) 抑制小鼠转移性黑色素瘤模型中的肿瘤生长[1]。
Nicotinamide (GMP Like) (腹腔注射，1800 mg/Kg，每天一次，小鼠转移性黑色素瘤模型) 影响 IFN-γ (细胞介导的抗肿瘤免疫的关键介质)，增加 Eotaxin 和 IL-5 的血浆水平，降低 IL-3、IL-12、RANTES 和 IL-10 的血浆水平[1]。
Nicotinamide (GMP Like) (静脉注射，0-200 mg/kg，5 天) 抑制 HBV 转基因小鼠体内的 HBV 复制[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (subcutaneous injected with B16-F10 cells)[1]
Dosage: 1000, 1500, 1800 mg/Kg.
Administration: Intraperitoneal injection, 5 days per week (followed by 2-day rest) or once a day.
Result: Inhibited tumor growth at 1500 and 1800 mg/Kg, and had no effect on the body weight.
Increased the frequency of IFN-γ producing cells and modulated the protein levels of cytokines and chemokines in the plasma of tumor-bearing mice.
Animal Model: HBV-transgenic mice[3]
Dosage: 0-200 mg/kg
Administration: Vein injection, 5 days
Result: Reduced serum HBV DNA.
分子量

122.12

Formula

C6H6N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nicotinamide (GMP Like) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nicotinamide (GMP Like)98-92-0Niacinamide (GMP Like)Nicotinic acid amide (GMP Like)Endogenous MetaboliteSirtuinHBVHepatitis B virusMelanomatumorA375 cellSK-MEL-28 cellskin cancerhESCsInhibitorinhibitorinhibit

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