2. Apoptosis
  3. Apoptosis
  4. NPD15261

NPD15261 (MI102) 是一种高选择性 MYCN 抑制剂。NPD15261 降低肝癌细胞中 MYCN 的 mRNA 和蛋白水平，抑制细胞增殖和集落形成，同时诱导细胞凋亡 (Apoptosis)。NPD15261 可用于肝癌的研究。

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NPD15261

NPD15261 Chemical Structure

CAS No. : 895901-42-5

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NPD15261 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NPD15261 (MI102) is a highly selective MYCN inhibitor. NPD15261 reduces the mRNA and protein levels of MYCN in liver cancer cells, inhibits cell proliferation and colony formation, and induces Apoptosis simultaneously. NPD15261 can be used in liver cancer research[1].

体外研究
(In Vitro)

NPD15261 (0-10 μM; 2 h) 可抑制 JHH7 细胞中基础状态下及 HGF 诱导的 MET 在 Y1234/Y1235 位点的磷酸化，其 IC50 为 0.77 μM，同时抑制 HGF 诱导的 Y1349 位点 MET 磷酸化[1]。
NPD15261 (0-10 μM) 以剂量依赖方式抑制 JHH7 细胞中 MYCN mRNA 和蛋白的表达，该效应可被 20 ng/mL HGF 刺激部分逆转[1]。
NPD15261 (0-5 μM; 4 days) 在 5 μM 浓度下选择性降低 JHH7 细胞的活力以及细胞球的存活率，而对正常 Hc 细胞无影响[1]。
NPD15261 (2.5-10 μM; 0-12 days) 抑制 JHH7 细胞的集落形成，呈剂量依赖性抑制 JHH7 细胞增殖[1]。
NPD15261 (2.5 μM; 24 h) 24 小时后可诱导 JHH7 细胞发生细胞凋亡，而对正常 Hc 细胞的细胞毒性极低[1]。
NPD15261 (5-10 μM; 6 h) 可下调 MYCN 相关的致癌通路 (包括 MYC_Targets_V2、MYC_Targets_V1 和 E2F_Targets)，并在处理 6 小时后选择性抑制 JHH7 细胞中的 MYCN 靶基因，而对正常 Hc 细胞无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NPD15261 相关抗体:

Western Blot Analysis[1]

Cell Line: JHH7 cells
Concentration: 0, 0.5, 1, 2.5, 5, 10 μM , with or without HGF (10 ng/mL)
Incubation Time: 2 h
Result: Inhibited the phosphorylation of MET at Y1234/Y1235 as well as HGF-induced phosphorylation at Y1234/Y1235 and Y1349 in a dose-dependent manner.
Inhibited MET phosphorylation at Y1234/Y1235 by approximately 83% at 1 μM, with an estimated IC50 value
of 0.77 μM.

Cell Viability Assay[1]

Cell Line: human hepatocellular carcinoma JHH7 cells, normal hepatic Hc cells
Concentration: 0, 0.2, 1, 5 μM
Incubation Time: 4 days
Result: Markedly reduced JHH7 cell viability at 5 μM.
Showed no observable effects on normal hepatic Hc cells.

Apoptosis Analysis[1]

Cell Line: human hepatocellular carcinoma JHH7 cells, normal hepatic Hc cells
Concentration: 2.5 μM
Incubation Time: 24 h
Result: Induced apoptosis in JHH7 cells.
Showed no significant cytotoxicity to normal hepatic Hc cells.
分子量

476.56

Formula

C28H32N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NPD15261 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPD15261895901-42-5MI102NPD 15261NPD-15261MI 102MI-102ApoptosisMYCN inhibitorJHH7 cellsliver cancer
Inhibitorinhibitorinhibit

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