1. Cell Cycle/DNA Damage Cytoskeleton
  2. Microtubule/Tubulin
  3. NSC 330770

NSC 330770 是一种去甲基化氢化分子,是一种强效的微管蛋白聚合 (tubulin polymerization) 抑制剂 (IC50 为 2 μM)。NSC 330770 可诱导 GTP 酶活性并促进异常聚合物的形成。

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NSC 330770

NSC 330770 Chemical Structure

CAS No. : 82585-91-9

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC 330770, a demethylated hydrogenated molecule, is a potent tubulin polymerization inhibitor (IC50 of 2 μM). NSC 330770 elicites GTPase activity and the formation of abnormal polymers[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
L1210 IC50
0.0047 μM
Compound: 1
The compound was tested for cell growth inhibitory activity against lymphoid leukemia L1210 cell line.
The compound was tested for cell growth inhibitory activity against lymphoid leukemia L1210 cell line.
[PMID: 2299631]
L1210 IC50
0.0047 μM
Compound: 29
Concentration required to inhibit 50% proliferation of cultured lymphoid leukemia L1210 cells was measured
Concentration required to inhibit 50% proliferation of cultured lymphoid leukemia L1210 cells was measured
[PMID: 2231603]
L1210 IC50
4.7 nM
Compound: 1d
Inhibitory activity against lymphoid leukemia L1210 cells
Inhibitory activity against lymphoid leukemia L1210 cells
[PMID: 2769680]
L1210 IC50
4.7 nM
Compound: 6
The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells
The compound was tested in vitro for growth of inhibitory activity against lymphoid leukemia L1210 cells
[PMID: 2795608]
L1210 IC50
4.7 nM
Compound: 6q
Cytotoxicity against lymphoid leukemia L1210 cells
Cytotoxicity against lymphoid leukemia L1210 cells
[PMID: 1956035]
分子量

311.34

Formula

C16H17N5O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
NSC 330770
目录号:
HY-148022
需求量: