2. Academic Validation
  3. New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-car bamate

New anticancer agents: chiral isomers of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7-car bamate

  • J Med Chem. 1989 Sep;32(9):2089-92. doi: 10.1021/jm00129a012.
C Temple Jr 1,  G A Rener
Affiliations

Affiliation

  • 1 Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305.
PMID: 2769680 DOI: 10.1021/jm00129a012
Abstract

Racemic ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazine-7- carbamate (1a) has shown antitumor activity in a variety of in vivo experiments. The preparation of the R and S isomers gave compounds with significant differences in potency in several biological tests.

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