2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. P-gp-IN-35

P-gp-IN-35 是一种 P-糖蛋白 (P-gp) 抑制剂。P-gp-IN-35 对敏感性乳腺癌和结直肠癌细胞具有细胞毒性，还可逆转过表达 P-gp 的乳腺癌细胞的多药耐药性。P-gp-IN-35 可用于多药耐药性乳腺癌和结肠癌的相关研究。

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P-gp-IN-35

P-gp-IN-35 Chemical Structure

CAS No. : 1887151-21-4

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P-gp-IN-35 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P-gp-IN-35 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-35 exhibits cytotoxicity against sensitive breast cancer and colorectal cancer cells, and can reverse multidrug resistance in breast cancer cells with P-gp overexpression. P-gp-IN-35 can be used in research related to multidrug-resistant breast cancer and colon cancer[1].

体外研究
(In Vitro)

P-gp-IN-35 (Compound 4d) (24 h) 可强效抑制 MCF-7、Caco-2 及多药耐药 MCF-7/ADR 癌细胞的增殖，其 IC50 值分别为 8.14、9.04 和 19.32 μM；相较于正常 HFL-1 和 WI-38 肺成纤维细胞，该化合物对癌细胞表现出选择性毒性[1]。
P-gp-IN-35 (1-100 μM; 48 h) 可浓度依赖性地下调 MCF-7/ADR 细胞中 P-糖蛋白的表达，在 100 μM 浓度下抑制率达 61.27%，并能逆转 P-gp 介导的多药耐药性，其 IC50 为 15.09 μM[1]。
P-gp-IN-35 可抑制 MCF-7/ADR 细胞中 P-糖蛋白外排泵的活性，其 IC50 为 47.08 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

P-gp-IN-35 相关抗体:

ELISA Assay[1]

Cell Line: MCF-7/ADR
Concentration: 1 μM, 10 μM, 100 μM
Incubation Time: 48 h
Result: Reduced P-gp expression by 17.55% at 1 μM.\nReduced P-gp expression by 35.6% at 10 μM.\n
Reduced P-gp expression by 61.27% at 100 μM.\n
Inhibited P-gp-mediated multidrug resistance in MCF-7/ADR cells with an IC50 of 15.09 μM.
分子量

364.78

Formula

C20H13ClN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P-gp-IN-35 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp-IN-351887151-21-4P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243lung fibroblast cell linesMCF-7/ADRMCF-7breast cancer cellscolon cancercolorectal cancer cellsmultidrug-resistant breast cancerGln721Caco-2Inhibitorinhibitorinhibit

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目录号：
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