2. GPCR/G Protein Neuronal Signaling MAPK/ERK Pathway Stem Cell/Wnt Epigenetics
  3. CGRP Receptor 5-HT Receptor ERK Epigenetic Reader Domain
  4. PCC0105005

PCC0105005 是一种双靶点 CGRP Receptor 拮抗剂 (IC50 = 1.01 nM)/5-HT1F Receptor 部分激动剂 (EC50 = 77.91 nM)。PCC0105005 在偏头痛大鼠模型中具有显著的疗效。PCC0105005 显著降低 CGRP 和 c-Fos 蛋白表达，抑制 ERK 和 CREB 的磷酸化水平。PCC0105005 可用于研究偏头痛。

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PCC0105005

PCC0105005 Chemical Structure

CAS No. : 2921670-99-5

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PCC0105005 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PCC0105005 is a dual-target CGRP Receptor antagonist (IC50 = 1.01 nM) and a partial agonist of 5-HT1F Receptor (EC50 = 77.91 nM). PCC0105005 shows significant efficacy in the rat model of migraine. PCC0105005 significantly reduces the expression of CGRP and c-Fos proteins, and inhibits the phosphorylation levels of ERK and CREB. PCC0105005 can be used for research on migraine[1].

IC50 & Target[1]

5-HT1F Receptor

77.91 nM (IC50)

ERK

 

分子量

894.12

Formula

C51H63N11O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PCC0105005 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCC01050052921670-99-5PCC 0105005PCC-0105005CGRP Receptor5-HT ReceptorERKEpigenetic Reader DomainCalcitonin gene-related peptide receptor Serotonin Receptor5-hydroxytryptamine ReceptorExtracellular signal regulated kinasesDual-target therapeuticsCGRP antagonists5-HT1F agonistsmigraine treatmentstructure-based drug designpharmacokineticsperipheral restrictiontrigeminovascular systemneurogenic inflammationpain thresholdInhibitorinhibitorinhibit

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产品名称：
PCC0105005
目录号：
HY-179684
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