2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. PF-06764427

PF-06764427 是一种选择性 M1 毒蕈碱型乙酰胆碱受体 (M1 muscarinic acetylcholine receptor) 正向变构调节剂。PF-06764427 具有显著的 M1 受体激动活性。PF-06764427 可用于阿尔茨海默病和精神分裂症的研究。

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PF-06764427

PF-06764427 Chemical Structure

CAS No. : 1842371-08-7

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PF-06764427 相关抗体

Top Publications Citing Use of Products

查看 mAChR 亚型特异性产品:

查看所有亚型
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-06764427 is a selective M1 muscarinic acetylcholine receptor positive allosteric modulator. PF-06764427 exhibits robust M1 agonist activity. PF-06764427 can be used in the research of Alzheimer's disease and schizophrenia[1][2].

IC50 & Target[1][2]

mAChR1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
55 nM
Compound: 25
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as acetylcholine-induced calcium mobilization by FLIPR assay
[PMID: 26631313]
分子量

431.49

Formula

C24H25N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-06764427 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-067644271842371-08-7PF06764427PF 06764427mAChRMuscarinic acetylcholine receptorAlzheimer's diseaseschizophreniaInhibitorinhibitorinhibit

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产品名称：
PF-06764427
目录号：
HY-123852
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