2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Melanocortin Receptor Interleukin Related
  4. PG-901

PG-901 是一种完全的、选择性的 MC5R 激动剂 (对 hMC5R 的 EC50 = 0.072 nM)。PG-901 也是 hMC3R 和 hMC4R 的完全拮抗剂 (Kb 分别为 1.0 nM 和 0.53 nM)。PG-901 可显著降低细胞因子 (IL-1α、IL-1β 和 IL-6) 的水平。PG-901 可提高葡萄糖耐量，降低血糖，并减少视网膜损伤。

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Custom Peptide Synthesis

PG-901

PG-901 Chemical Structure

CAS No. : 322639-20-3

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PG-901 相关抗体

Top Publications Citing Use of Products

查看 Melanocortin Receptor 亚型特异性产品:

查看所有亚型
MC1R MC3R MC2R MC4R MC5R

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PG-901 is a full, selective MC5R agonist (EC50 = 0.072 nM for hMC5R). PG-901 is also a full antagonist at the hMC3R and the hMC4R (Kb: 1.0 nM and 0.53 nM, respectively). PG-901 significantly diminishes Cytokines (IL-1α, IL-1β, IL-6). PG-901 increases glucose tolerance, reduces blood glucose, decreases retinal damage[1][2][3].

IC50 & Target[1][2][3]

MC5R

0.072 nM (EC50)

MC3R

1.0 nM (Kb)

MC4R

0.53 nM (Kb)

IL-1β

 

IL-1α

 

IL-6

 

分子量

1034.21

Formula

C53H71N13O9
CAS 号
Sequence

Ac-{Nle}-cyclo(Asp-Pro-{d-Nla}-Arg-Trp-Lys)
Sequence Shortening

Ac-{Nle}-cyclo(DP-{d-Nla}-RWK)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PG-901 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PG-901322639-20-3PG901PG 901Melanocortin ReceptorInterleukin RelatedMC ReceptorILblood glucoseretinal damageInhibitorinhibitorinhibit

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目录号：
HY-P11469
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