2. 多肽产品
  3. 多肽及其衍生物
  4. 抑制剂与底物肽
  5. Phakellistatin 13

Phakellistatin 13 是一种具有抗肿瘤活性的天然环七肽。Phakellistatin 13 对肝癌细胞 BEL-7404 表现出强效抑制作用 (ED50 < 0.01 μg/mL)。Phakellistatin 13 可用于研究肝癌。

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Custom Peptide Synthesis

Phakellistatin 13

Phakellistatin 13 Chemical Structure

CAS No. : 493012-52-5

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Phakellistatin 13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phakellistatin 13 is a natural cycloheptapeptide with anti-tumor activity. Phakellistatin 13 exhibits a potent inhibitory effect on liver cancer cells BEL-7404 (ED500 < 0.01 μg/mL). Phakellistatin 13 can be used for research on liver cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
26.8 μM
Compound: Phakellistatin 13
Antiproliferative activity against mouse 4T1 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against mouse 4T1 cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
Bel-7402 ED50
< 0.01 μg/mL
Compound: 3
Cytotoxicity against human Bel-7402
Cytotoxicity against human Bel-7402
[PMID: 17190452]
HeLa IC50
28.05 μM
Compound: Phakellistatin 13
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
HepG2 IC50
13.1 μM
Compound: Phakellistatin 13
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
L929 IC50
> 100 μM
Compound: Phakellistatin 13
Antiproliferative activity against mouse L929 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against mouse L929 cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
MDA-MB-231 IC50
20.5 μM
Compound: Phakellistatin 13
Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay
[PMID: 38990190]
分子量

798.93

Formula

C42H54N8O8
CAS 号
Sequence

cyclo(Pro-Phe-Gly-Pro-Thr-Leu-Trp)
Sequence Shortening

cyclo(PFGPTLW)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Phakellistatin 13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phakellistatin 13493012-52-5Otherscyclic peptidyl antitumor agentsisoindolinoneconformational constraintp53 signaling pathwayMAPK signaling pathwaymolecular dockingtranscriptome analysisapoptosis inductionhepatocellular carcinomInhibitorinhibitorinhibit

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